“EFFECT OF HOMOEOPATHIC MEDICINE TRIBULUS TERRESTRIS Q, 6C, 12C, 30C, 200C, 1M AS AN INHIBITOR OF CALCIUM OXALATE AND CALCIUM PHOSPHATE CRYSTALLIZATION IN VITRO STUDY”
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Published:2021-09-01
Issue:
Volume:
Page:45-48
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ISSN:
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Container-title:INTERNATIONAL JOURNAL OF SCIENTIFIC RESEARCH
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language:en
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Short-container-title:ijsr
Author:
Shankar Gowda Sharada1, A. Khan Tanveer2, Namdeo Ajay3, H. Shinde Chetan1
Affiliation:
1. Post-graduate Scholar, Department of Homoeopathic Pharmacy, Bharati Vidyapeeth (Deemed to be University), Homoeopathic Medical College and Hospital, Dept. of Post graduate & Research Centre, Pune-Satara road, Dhankawadi, Pune, India 411043. 2. Principal, Bharati Vidyapeeth (Deemed to be University), Homoeopathic Medical College and Hospital, Dept. of Post graduate & Research Centre, Pune-Satara road, Dhankawadi, Pune, India 411043. 3. Associate Professor, Department of Pharmacognosy, Bharati Vidyapeeth (Deemed to be University), Poona College of Pharmacy, Erandwane, Pune. India 411052
Abstract
Background: Urolithiasis is one of the common conditions in the society and it needs medical attention due to its increase in prevalence. The use of
the homeopathic medicines has found to be,of great importance in the treatment of urolithiasis and certainly homoeopathy is a promising eld in
this condition.
Objectives: The aim of this study was to evaluate the mechanism of urolithiasis and the inhibitory action of homeopathic drug Tribulus terrestris by
in vitro experiment.
Materials and Method: Homoeopathic preparation of Tribulus terrestris Q, 6C, 12C, 30C, 200C, 1M was planned to evaluate in vitro calcium
oxalate and calcium phosphate crystallization using spectro-photometric and colorimetric assay respectively. Considering the role of reactive
oxygen species as one of the etiological factors in stone formation, effective antioxidant activity of Tribulus terrestris was also performed by 2,2-
diphenyl -1-picrylhydrazyl (DPPH) free radical scavenging assay.
Result: Tribulus terrestris Q, 200C and 1M exerted maximum inhibition as 33.62%, 23.89% and 23.00% respectively to calcium oxalate
nucleation assay whereas, Tribulus terrestris Q, 6C, 12C, 30C, 200C, 1M exerted maximum inhibition to calcium oxalate aggregation assay up to
76.19%. Tribulus terrestris 12C and 30C showed maximum inhibition as 82.28% and 16. 21% to calcium and phosphate ions respectively. Presence
of antioxidant activity by DPPH radical assay for Tribulus terrestris Q and 12C which showed percentage inhibition as 33.11% and 0.95%
respectively.
Conclusions:Homoeopathic preparation Tribulus terrestris has potential effect on inhibition of calcium oxalate and calcium phosphate
crystallization and also homoeopathic preparation of Tribulus terrestris is capable of showing presence of phytochemicals; anti-oxidant activity
when performed by in vitro experiment.
Publisher
World Wide Journals
Reference18 articles.
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