A COMPARATIVE STUDY OF INTRAARTICULAR PRPAND HYALURONIC ACID FOR OSTEOARTHRITIS KNEE JOINT

Abstract

Intrarticular injections with PRP and HAcan be quite benecial to treat OAknee patients that cannot be managed by analgesics and physiotherapy alone. However, there is no consensus regarding the better efciency of PRP vs HA till now. Hence, this study compares the efciency of these procedures in terms of clinical outcomes as measured by functional and pain assessment. This hospital based prospective randomised trial was conducted among 100 patients (50 study group and 50 in control group), selected using simple randomisation sampling. The functional assessment after both procedures was evaluated at 6 weeks, 3 months, 6 months and 1 year using the WOMAC scale and VAS scale. The p-value using unpaired t-test in comparison between the two groups not statistically signicant through all the follow up periods showing that PRPwas not superior to HA even though both the groups showed signicant improvement in the WOMAC scores at all follow up points (p=0.215 ;6 weeks, p=0.961; 3 months,p=0.738;6 months) .Group I VAS shows a reduction in mean of 7.3 to 3.1 which denotes improvement in the patient's pain There was a signicant reduction of VAS mean from 7.04 to 3.04 in Group II, showing signicant improvement in pain.The p value was not statistically signicant when comparing the 2 groups (p=0.807) Our studies conclude that both modalities were efcient in improving the functional status of the knee and reduce symptoms of OA, PRP did not provide superior clinical improvement compared with HA in symptomatic or functional improvement at different follow-up stages.