Affiliation:
1. Shree Dhanvantary Pharmacy College, Kim, Surat, Gujarat.
2. Laxminarayandev College of Pharmacy, Bharuch, Gujarat. Yashwantrao Bhonsale College of Pharmacy, Sawantwadi, Maharashtra.
Abstract
Pregabalin capsules, extended-release (long-acting) tablets and oral solution (liquid) are used to relieve neuropathic pain (pain from damaged
nerves) and also used in spinal cord injury and to treat bromyalgia (a long-lasting condition that may cause muscle stiffness and tenderness,
tiredness, pain, and difculty falling asleep) as well as in epilepsy, so determination of pregabalin in various dosage form is very important, but
direct determination of pregabalin in pharmaceutical dosage form is quite difcult as pregabalin is an aliphatic agent (absence of any chromophoric
group). Addition of chromophoric group – derivatization of pregabalin is necessary for effective determination of pregabalin in pharmaceutical
dosage form. Derivatization of pregabalin is done with various derivatizing agent – benzyl chloride, ninhydrin, , Gibb's and MBTH reagent 1-
Fluoro-2,4-dinitrobenzene for spectroscopic method. For HPLC method, pre coloum and post coloum derivatization is done with Na-5- uoro-2,
4-dinitrophenyl-5-L-alanine amide, o-phtaldialdehyde/2-mercaptoethanol.
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