EXPRESSION OF OCT-4 STEM CELL MARKER IN URINARY BLADDER CANCER AND ITS CORRELATION WITH INVASIVENESS

Author:

Jain Suvigya1,Srivastava A N2,Jain Manoj3,Lal Nirupma4,Ahmad Sharique5,Singh Shivani6

Affiliation:

1. Medical Intern, Era's Lucknow Medical College and Hospital, Era University, Lucknow, Uttar Pradesh. India-226003.

2. Director Research, Department of Pathology, Era's Lucknow Medical College and Hospital, Era University, Lucknow, Uttar Pradesh. India -226003.

3. Professor, Department of Pathology, SGPGI, Lucknow, Uttar Pradesh. India -226014.

4. Professor, . Department of Pathology, Era's Lucknow Medical College and Hospital, Era University, Lucknow, Uttar Pradesh. India -226003.

5. Professor, Department of Pathology, Era's Lucknow Medical College and Hospital, Era University, Lucknow, Uttar Pradesh. India -226003

6. Research Assistant. Department of Pathology, Era's Lucknow Medical College and Hospital, Era University, Lucknow, Uttar Pradesh. India -226003.

Abstract

This study’s objective is to evaluate the expression of Octamer-binding transcription factor 4 (OCT-4) as a prognostic biomarker for urinary bladder cancer (UBC) along with its histological grade and tissue invasiveness. It is also called the POU domain, class 5, transcription factor I(POU5FI). OCT-4 protein is a transcription factor and a well-known marker of cancer stem cells. This study aimed to validate the OCT-4 value in urinary bladder cancer. FFPE tissue blocks from ten patients of different grades and invasiveness of urothelial carcinoma were studied and correlated with the degree of OCT-4 expression by immunohistochemistry. The mean histochemical expression score in seven high-grade urothelial carcinoma cases was 8.4 as compared to 5.0 in three low-grade urothelial carcinoma cases. Similarly, the mean histochemical expression score in seven lamina invasive urothelial carcinoma was 5.9 as compared to 7.5 in detrusor muscle-invasive urothelial carcinoma. There was a positive correlation between OCT-4 expression and high grade and invasive urinary bladder cancer.

Publisher

World Wide Journals

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