Affiliation:
1. 2 Year Junior Resident, Dept. of Pathology Narayan Medical College Sasaram Bihar.
2. 1 Year Junior Resident, Dept. of Pathology Narayan Medical College Sasaram Bihar.
3. 2 Year Junior Resident Dept. of General Surgery Narayan Medical College Sasaram Bihar.
Abstract
Objective: The most widely accepted hypothesis is bile stasis caused by gall bladder dyskinesia. The aim of this study is to investigate about
relationship between gall stones and different gall bladder pathologies. Specimens for study was sent by surgery department forMethods:
histopathology after cholecystectomy. After grossing, sections were submitted for tissue processing. Grossly, size of gall bladder wasResults:
normal in 91 (60.66%) but brotic in 15 (10%) and enlarged in 44 (29.34%) patients. Wall thickness was normal (3 mm) in 71 patients (47.33%). In
microscopy 110 (73.34%) were of chronic cholecystitis, cholesterolosis 15 (10%) cases, xathogranulomatous and acute on chronic cholecystitis 3
cases (2%) each, 1 case (0.67%) each of mucocele and follicular cholecystitis. Hyperplasia was observed in 8 (5.33%) cases. Hyperplasia
subclassied into adenomatous and adenomyomatous. Five (3.33%) cases of cholecystitis with metaplasia were seen. There were 4 cases (2.66%)
of carcinoma, predominant histologic type being adenocarcinoma. Presence of stones may lead to different mucosal changes fromConclusion:
chronic inammation to carcinoma. Therefore histopathological examination of all cholecystectomy specimens with or without cholelithiasis is
essential to diagnose benign as well as malignant pathology.
Reference16 articles.
1. Baig SJ, Biswas S, Das S, Basu K and Chattopadhyay G. Histopathological changes in gallbladder mucosa in cholelithiasis: correlation with chemical composition of gallstones. Trop Gastroenterol 2002; 23:25-27.
2. Meyer G, Guizzardi F, Rodighiero S, Manfredi R, Saino S, Sironi C, et al. Ion transport across the gallbladder epithelium. Curr Drug Targets Immune Endocr Metabol Disord 2005; 5:143-151.
3. Aust S, Obrist P, Jaeger W, Klimpfinger M, Tucek G, Wrba F, et al. Thalhammer T Subcellular localization of the ABCG2 transporter in normal and malignant human gallbladder epithelium. Lab Invest 2004; 84:1024-1036.
4. Kuver R, Klinkspoor JH, Osborne WR, Lee SP. Mucous granule exocytosis and CFTR expression in gallbladder epithelium. Glycobiology 2000; 10:149-157.
5. Afdhal NH. Choleterol crystal nucleation: A decadelong search for the missing link in gallbladder pathogenesis. Hepatology 1990, 11:669-702. Chetan Haryana Airtel, [07.04.19 12:19].