Affiliation:
1. Junior Resident, Department of Dermatology, Venereology and Leprosy, Chettinad hospital and research institute, Tamil Nadu
2. Professor and Head of the Department, Department of Dermatology, Venereology and Leprosy Chettinad hospital and research institute, Tamil Nadu
Abstract
Dowling-Degos disease is an uncommon genetic disorder commonly seen in women inherited as an autosomal dominant trait characterized by
reticulate pigmentation over the intertriginous areas distributed symmetrically. The pigmentation is not congenital and age of presentation can be
variable. We report the case of 35-year-old woman who came with complaints of asymptomatic pigmentation over the exural areas.
Subject
General Economics, Econometrics and Finance,General Social Sciences,Health, Toxicology and Mutagenesis,Public Health, Environmental and Occupational Health,Multidisciplinary,General Chemical Engineering,Law,Surfaces, Coatings and Films,General Energy,Mechanical Engineering,Industrial and Manufacturing Engineering,Strategy and Management,Computer Science Applications,Industrial relations,Management Information Systems,Marketing,General Engineering,Developmental and Educational Psychology,Education,Engineering (miscellaneous),Instrumentation
Reference15 articles.
1. Jayakar Thomas, Hemadharshini B, Tamilarasi S, Asha D, Manoharan D. Dowling-Degos disease-a case report. Jayakar Thomas et al. / International Journal Of Advances In Case Reports, 2015;2(16):1047-1049.
2. Kim YC, Davis MD, Schanbacher CF, Su WP. Dowling-Degos disease (reticulate pigmented anomaly of the flexures): a clinical and histopathologic study of 6 cases. J Am Acad Dermatol. 1999;40:462–467.
3. Dowling GB, Freudenthal W. Acanthosis Nigricans. Proc R Soc Med 1938; 31:1147-50.
4. Degos R, Ossipowski B. [Reticulated pigmentary dermatosis of the folds: relation to acanthosis nigricans]. Ann Dermatol Syphiligr (Paris) 1954; 81:147- 51.
5. Betz RC, Planko L, Eigelshoven S, Hanneken S, Pasternack SM, Bussow H, et al. Loss-of-function mutations in the keratin 5 gene lead to Dowling- Degos disease. Am J Hum Genet 2006;78:510-9.