EARLY PREGNANCY MATERNAL VITAMIN D DEFICIENCY AND RISK OF GESTATIONAL DIABETES MELLITUS IN LIBYAN PREGNANT WOMEN-Reference-Cited by-同舟云学术

EARLY PREGNANCY MATERNAL VITAMIN D DEFICIENCY AND RISK OF GESTATIONAL DIABETES MELLITUS IN LIBYAN PREGNANT WOMEN

Published:2020-09-01 Issue: Volume: Page:1-4
ISSN:
Container-title:INDIAN JOURNAL OF APPLIED RESEARCH
language:en
Short-container-title:IJAR

Author:

Getlawi Omaima H.¹,narasamma Vellanki. Lakshmi²,Hawda Salima M.³,Busarira Musa O.⁴,Fadeel Eman E.⁵,Teja Peela Laxmi⁶,Nauhria Samal⁷,Barke Pragna⁸,Rao Peela Jagannadha⁹

Affiliation:

1. Department of obstetrics and gynecology faculty of medicine Benghazi university

2. Associate prof of Biochemistry, Govt Medical college Balaga, Srikakulam,AP,India.

3. Department of Biochemistry faculty of medicine Benghazi university

4. Department of Obstetrics and Gynaecology, Faculty of medicine, Benghazi University, Benghazi,Libya.

5. Department of Obstetrics and Gynaecology, Faculty of medicine, Benghazi University, Benghazi,Libya

6. Junior Resident, Department of General Surgery, NRI Institute of Medical Sciences Visakhapatnam, AP, India

7. MBBS, MD Associate Professor, Department of Pathology, St.Matthews University. Grand Cayman, Cayman Islands.

8. Department of Physiology, School of Medicine St Matthews University Grand Cayman,Cayman islands.

9. Department of Biochemistry and Genetics, School of Medicine St Matthews University, Grand Cayman, Cayman islands

Abstract

Background Vitamin D deficiency is a common occurrence, which affects maternal health during pregnancy. Evidence is accumulating for a role of a low level of vitamin D during the early pregnancy as a risk factor for the development of gestational diabetes mellitus (GDM). Our objectives are to describe the patterns of vitamin D levels in early pregnancy in mothers attending main antenatal services in Ajdabiya city, during the first quarter of the year 2017 and to examine the relationship between vitamin D levels and glucose metabolic derangements in pregnant women among the above-described population. Methods A cohort study was conducted in healthy pregnant women attending routine antenatal care in Ajdabiya city in 2017. All mothers were screened for serum 25 (OH) D level and glycated hemoglobin (HbA1c) and anthropometric by the time of booking during the first trimester (gestational age "GA" 7-15th week of pregnancy). All women with low 25 (OH) D level were screened for GDM with non-fasting post-challenge blood glucose and confirmed by OGTT according to the American Diabetes Association (ADA) classification of GDM criteria in their 2nd trimester. Data was analyzed by using SPSS, IBM 20.0. Results All mothers in the study population were Libyan, their ages ranged from 18-43 years. Parity ranged from nulliparous to P10. More than 60% of mothers were housewives while others were either working or students and considered as having an outdoor lifestyle. In the first trimester, we detected 412 mothers had serum vitamin D3 below normal, the majority of cases had deficient serum 25 (OH) D (391, 94.9%) while 21 (5.1%) women had an insufficient serum 25 (OH) D. Serum 25 (OH) D ranged from 5.9-30.0 ng/ml. In the 2nd trimester, we confirmed 43 (10.43%) pregnant women with GDM out of 391 women with deficient serum 25 (OH) D level. 25 (OH) D deficiency was statistically significant (p = 0.035, OR = 0.963, 95% CI = 0.881-0.996) and associated with all GDM cases. Conclusion We conclude that 25 (OH) D deficiency was significantly correlated with GDM, as a consequence, the deficiency of 25 (OH) D could act as a risk factor for GDM. This result implies the necessity of focusing on vitamin D3 supplementation for women of childbearing age.

Publisher

World Wide Journals

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