Affiliation:
1. Consultant Pathologist, Medall Health Care, Vijayawada
2. Assitant Professor, Department of Pathology, Bowring & Lady Curzon Medical College, Bangalore
3. Consultant Pathologist, Trinity Fertility sevices, Hyderabad
Abstract
Ovarian malignancy is one of the most common cancers contributing to signicant morbidity and mortality. Tumour vascularization is critical to
growth and metastasis of the tumour determining the course of disease. Microvessel density is a reliable indicator of degree of vascularization in a
tumour and can be used as a parameter to compare aggressiveness. The purpose of this study was to evaluate the degree of tumour vascularization
across a spectrum of surface epithelial ovarian tumours by calculating microvessel density. Immunohistochemistry was used to identify CD34 and
quantify the microvessels observed. Our study revealed that malignant ovarian tumours have a higher microvessel density as compared to benign
and borderline tumours. This nding is signicant in context of treatment of advanced ovarian cancers by anti-angiogenic drugs to improve
survival rates. Hence, microvessel density is an important prognostic factor in ovarian malignancy and can be used to monitor treatment using
novel targeted therapy.
Subject
Agronomy and Crop Science,Applied Microbiology and Biotechnology,Bioengineering,Food Science,Biotechnology,Biochemistry,Catalysis,Biotechnology,Cell Biology,Molecular Biology,Biochemistry,Biophysics,Biochemistry,Biochemistry,Biomedical Engineering,Environmental Engineering,Bioengineering,Biotechnology,Genetics,Molecular Biology,General Medicine,Ecology, Evolution, Behavior and Systematics,Biochemistry,Cell Biology,Molecular Biology,Biochemistry,Biochemistry,Organic Chemistry,Molecular Biology,Applied Microbiology and Biotechnology,General Medicine,Biochemistry,Analytical Chemistry,Biotechnology
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