THE STUDY OF AUTONOMIC FUNCTIONS IN YOUNG NONDIABETIC OFFSPRINGS OF TYPE 2 DIABETES MELLITUS PARENTS BY FREQUENCY DOMAIN ANALYSIS OF HEART RATE VARIABILITY

Abstract

INTRODUCTION: Children with parental history of diabetes have inherited susceptibility to develop diabetes. It has been shown that patients with Diabetes Mellitus exhibit altered autonomic activity of cardiovascular system. The present study aimed to determine the early changes in cardiac autonomic modulation by measuring the frequency domain analysis of heart rate variability among healthy subjects with parental history of type 2 diabetes and to compare it with the age and sex matched controls. The study of Cardiovascular Autonomic FunctionsMETHODOLOGY: was carried out in 50 healthy offsprings of Type 2 Diabetic Parents (Case group) and 50 healthy offsprings of Nondiabetic Parents (Control group) in the age range of 18 - 25 years randomly selected among MBBS students of J.L.N. Medical College Ajmer. Statistical Analysis is done by student t-test. Probability P value <0.05 was considered statistically signicant. In offsprings of type 2 diabetic patients signicantly lower HFRESULT: (nu) and signicantly higher LF (Nu) and LF/HF ratio were observed as compared to control group. The present study revealsCONCLUSION: that the Sympathovagal Imbalance (SVI) was due to vagal withdrawal in offspring of type 2 Diabetes Mellitus patients. Impairment in autonomic function is associated with increased risk of future diabetes. Early detection of diabetes can be used for risk stratication at early stages of life and serious consequences can be reduced.