ANALYSIS AND CORELATION OF A PANEL OF SERUM BIOMARKERS WITH TREATMENT OUTCOME OF ISCHEMIC HEART DISEASE IN A TERTIARY CARE HOSPITAL OF WEST BENGAL

Abstract

Background :In India Ischemic heart disease (IHD ) is the of most common causes of mortality and morbidity . Several studies have pointed out a strong association of serum Lipoprotein (a) , Homocysteine and highly sensitive – C reactive protein [hs-CRP],with IHD , but these markers have been studied in isolation . Aim: The aim of the study was to assess diagnostic potential of the above biomarkers as well as their ability to reect treatment outcome. Results : The results of statistical analysis showed that levels of serum Lp (a) and serum homocysteine were signicantly raised in patients in of IHD compared to their apparently age and sex matched controls whereas the level of serum hsCRP level did not showed any signicant difference in between cases and controls. We also found signicant lower value of serum level Lp (a), homocysteine and hsCRP in 3 months and 6 months post treated cases compared to untreated cases of IHD. But failed to show any signicant correlation in between serum levels of Lp(a) , hsCRP and Homocysteine level with disease severity( LVEF%) of IHD. Conclusion :So the serum Lp(a) , hsCRP and Homocysteine level is associated with increase risk factor of IHD and would be a better upcoming diagnostic and marker for diagnosis of IHD patients .