COVAGAL HYPOTHESIS : THE CONNECTION BETWEEN COVID AND VAGUS .

Abstract

The Coronavirus SARS CoV2 is a part of Coronaviridae family. The virus has overwhelmed the entire world with millions of deaths being reported each day. New variants of the virus are causing havoc in almost all parts of the world. India is witnessing a second wave of this pandemic in 2021. Scrutinizing and correlating data from over thousands of studies, the authors have conceptualized a basic pathophysiology and natural course of the disease. The authors propose a novel understanding of the disease, its epidemiology, symptoms and a targeted treatment protocol for the fatal virus. We shall be referring the SARS CoV2 variant of 2021 causing second wave of pandemic in India as the Rhabid Covid Virus (RCV) for better understanding of our hypothesis. The RCV is a single stranded RNA virus similar to the Rhabdovirus. The Rhabdovirus has neurovirulent action and the human coronaviruses have neuroinvasive properties. The RCV has both neurovirulent and neuroinvasive properties. We have hypothesised that vagus nerve is the main nerve affected by RCV. The symptoms that follow conform to the stages of injury, degeneration and regeneration of vagus nerve along with stages of myelin clearance. Based on our hypothesis, we have classied this disease into three stages. We have also introduced a new treatment protocol contingent on the stage of the disease presented.Our aim behind this hypothesis is to encourage clinical trials based on our protocol such that new and effective targeted treatment can be introduced against this deadly virus.