MANAGEMENT OF PRIMARY HYPERADOSTERONISM : DON'T WAIT UNTIL IT'S TOO LATE

Abstract

Introduction: Arterial hypertension by primary hyperaldosteronism is the most frequent cause of endocrine hypertension. It is responsible for 10% of endocrine arterial hypertension. In our context, there is a delay in the diagnosis of primary hyperaldosteronism because it is under traked and also because of the high cost of check-ups. The aim of our study is to highlight the challenges in the management of these patients. This observational study i Material And Method: ncludes patients admitted at the department of endocrinology of Sheikh Khalifa Ibn Zayd universitary hospital for primary aldosteronism between January 2019 and January 2021. Primary hyperaldosteronism was dened according to the Consensus on Primary Hyperaldosteronism of The French Society of Endocrinology (SFE), in collaboration with the French Society of Hypertension (SFHTA) and the French Association of Endocrine Surgery (AFCE). For all patients, we collected demographic characteristics, familial history of hypertension and cardiovascular diseases, patient's history of hypertension and its complications. We performed biological assessments and imaging investigations. We included 10 patients .The mean age of patients Results: was 42.5 years (+/-12.06). 7/10 of patients was males. We found a family history of hypertension in 7/10 of the cases . The mean age of onset of arterial hypertension was 36.4 years (+/-7,87) . Grade 3-hypertension was found in 4/10 of the cases. Hypokalemia was found in 6/10 of the cases. The etiological investigation found bilateral adrenal hyperplasia in 4/10 of the cases. Among them 5/10 have performed catheterization of the adrenal veins, which revealed lateralization of aldosterone secretion. Conn's adenoma was found in 4/10 of the cases and unilateral adrenal hyperplasia in 2/10 of the cases. Our study illustrate the value of screening for Conclusion: primary hyperaldosteronism in young subjects with severe hypertension associated with hypokalemia and also given the curable and reversible nature of hypertension.