A PROSPECTIVE STUDY ON CORRELATION OF SERUM LIPID PROFILE AND SEPSIS SEVERITY IN ADULT PATIENTS DIAGNOSED WITH SEPSIS IN A TERTIARY CARE HOSPITAL.

Abstract

Introduction: Sepsis causes, extensive physiological and biochemical abnormalities. Literature shows that infections cause reasonable alterations in lipid metabolism and in the composition of lipoproteins. In these situations, there is an increase in the levels of triglycerides and VLDL cholesterol and decrease in levels of HDL and LDL cholesterol. Patients with sepsis, having hypocholesterolaemia indicates disease severity when other causes of this condition are to be ruled out. Hence this study was done to understand the role of serum lipids in patients with sepsis. Material and methods: A prospective study was done in 60 adults patients admitted with sepsis (According to the Third International consensus Denitions for Sepsis and Septic Shock 2016 (Sepsis – 3), in medical wards and medical ICU of a tertiary care teaching hospital during December 2021 to April 2022 after obtaining institutional ethical committee clearance and consent from patients. All patients who gave informed consent were enrolled consecutively till the sample size was reached. Patients were subjected to detailed history taking, clinical examination and biochemical investigations were done and data was recorded in a semi-structured questionnaire. Data was entered in MS excel and analysis was done using SPSS -20, Data represented in frequency tables. Correlation between parameters assessed and APACHE II and SOFA score was done using pearsons correlation coefcient with P<0.05 considered as statistically signicant. Mean age of the study population was 40.22±11.831. Results: Majority of the study patients were males (71.7%). Respiratory tract infection (33/55%) was the major source of infection. Diabetes mellitus was the most common type of comorbidity (27/ 45%). HDL cholesterol was negatively correlated with both sepsis prognostic severity scores (APACHE II and SOFA score) which were highly signicant statistically. Pearsons correlation coefcient shows that total cholesterol, LDL cholesterol is poorly correlated with sepsis severity and triglycerides though negatively correlated the association is weak. Sepsis Conclusions: patients, shows alterations in lipid metabolism. Higher values of SOFA and APACHE II scores were associated with low HDL levels. Lipoproteins may function as potential biomarkers (especially high-density lipoprotein) in systemic inammatory response syndrome and sepsis