THE SIGNIFICANCE OF TRANSAMINASES AND DERITIS RATIO FOR PREDICTING ALCOHOLIC LIVER DISEASE

Abstract

Background: A signicant public health issue is alcoholic liver disease (ALD). At any stage of the disease, the Deritis ratio (AST/ALT) is more sensitive than other standard criteria in detecting biochemical abnormalities in ALD. This study's objective was to evaluate the importance of transaminases and the Deritis ratio as well as their potential prognostic value in alcoholic liver disease patients. Materials and Methods: It was a hospital-based retrospective study that used information kept in the Biochemistry department of Sri Venkateswara Medical College in Tirupati. Age, gender, total protein, albumin, AST, ALT, and AST/ALT ratio were the factors that was gathered. Descriptive statistics and hypothesis testing was analysed. Software tools EPI INFO and SPSS 23 was used to examine the data. Results: The percentage of ALD among the 50 patients was projected with 50 controls. Odds Ratio=3.2, p=0.0001, was 3.2 times more likely to develop above 40yrs of age. In ALD patients, the mean AST value (171.5 SD 94.46 IU/L) was substantially higher than the ALT value (85.12 SD 58.24 IU/L), resulting in a higher AST/ALT ratio (2.01 SD 0.58). When comparing the Deritis ratio in controls and cases, mean values are 0.78 with CI (1.02, 1.06) and 2.01 with CI (1.49, 1.69) respectively which showed higher signicance(p=0.001) in cases. An AST:ALT ratio >2 with CI (93.9%, 99.9%) was present in 96.9% of individuals with alcoholic liver disease. Each variable's mean value in cases was considerably higher than in controls (p 0.001). Conclusion: Due to its widespread use, ethanol consumption causes various liver illnesses, each of which is extremely serious. Equally crucial is to know its complication and to know its magnitude of impact. To grasp the extent of damage in alcoholic liver disease rationally, the assessment of the Deritis ratio is helpful.