PAPILLARY SQUAMOTRANSITIONAL CELL CARCINOMA OF THE CERVIX: A RARE CASE WITH REVIEW OF LITERATURE

Abstract

Background: Papillary squamotransitional cell carcinoma (PSTCC) of the cervix is a rare malignancy, a subtype of transitional carcinoma cervix. Here we are presenting a rare case of PSTCC of the cervix treated with surgery followed by adjuvant radiotherapy. Case report : A 44 years old lady presented with chief complaints of irregular menstrual cycles since 8 months associated with lower abdominal pain. MRI-Pelvis showed a 2.1cm×1.5cm×2.8cm cervical lesion. She underwent radical hysterectomy with bilateral salpingo-oophorectomy. Post-operative histopathology was suggestive of inltrating PSTCC of cervix with tumor size 3 cm × 2.5 cm involving the endocervical canal with rd lymphovascular invasion and cervical stromal invasion was more than 1/3 ,0/10 lymph nodes were involved and margins were negative. She received external beam radiotherapy to whole pelvis to a dose of 50 Gray (Gy) in 25 fractions followed by 2 sessions of intravaginal brachytherapy 18 to a dose of 8 Gy per fraction. FDG PET-CT done subsequently at one year of follow up was suggestive of complete metabolic response. Conclusion: PSTCC of cervix is rare entity and there is limited data available in the literature. Early stage PSTCC should be treated with surgery followed by adjuvant RT, as in our case, which yielded good local control and distant metastasis free survival.