SIMULTANEOUS ESTIMATION OF IVABRADINE HCl AND BISOPROLOL FUMARATE BY UV-SPECTROSCOPIC METHOD-Reference-Cited by-同舟云学术

SIMULTANEOUS ESTIMATION OF IVABRADINE HCl AND BISOPROLOL FUMARATE BY UV-SPECTROSCOPIC METHOD

Published:2022-04-15 Issue: Volume: Page:131-134
ISSN:
Container-title:GLOBAL JOURNAL FOR RESEARCH ANALYSIS
language:en
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Author:

Pandit Pushpak¹,Sheth Vraj¹,Viradiya Savan¹,Patel Mansi¹,A. Shah Dimal¹,K. Chhalotiya Usmangani¹

Affiliation:

1. Indukaka Ipcowala College of Pharmacy, New Vallabh Vidyanagar, Gujarat, India.

Abstract

A simple UV spectrophotometric analytical method has been developed for simultaneous estimation of Ivabradine HCl and Bisoprolol used in the treatment of angina pectoris. Modied simultaneous equation method was developed with double beam UV-Visible spectrophotometer using water as a solvent. The method was found to be linear in the range of 4-16 µg/ ml of Bisoprolol and 08-32 µg/ ml of Ivabradine. Percentage recovery for bisoprolol and Ivabradine by this method was found in the range of 96.43-100.60% and 95.80-100.10 %, respectively. The method was validated with respect to accuracy, precision, specicity and robustness as per ICH guideline. The method was applied for the estimation of laboratory prepared mixture and was found to be accurate and precise.

Publisher

World Wide Journals

Reference39 articles.

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