Affiliation:
1. Assistant Professor In The Department Of Pathology, Kakatiya Medical College, Warangal, Telangana
2. Assistant Professor In Pathology In Osmania Medical College
3. MD (General Medicine)
Abstract
Colorectal cancer is one of the most life-threatening gastrointestinal diseases encountered in
clinical practice.1 The rectum is one of the most frequently involved sites and accounts for 25% of
primary colorectal cancers.2 Accumulation of molecular alterations, including K-ras, P53, Bcl-2 and adenomatous polyposis
coli, contribute to colorectal carcinogenesis.3 According to the literature, the deletion of p53 with the overexpression of
p53 protein is correlated with a low rate of survival, thus being an independent prognosis factor.17 Summary:
Overexpression of p53 protein is associated with high grade of colorectal carcinoma.
Subject
Paleontology,Stratigraphy,Geology,Building and Construction,Architecture,Human Factors and Ergonomics,Orthopedics and Sports Medicine,Industrial and Manufacturing Engineering,Polymers and Plastics,Mechanical Engineering,Mechanics of Materials,Civil and Structural Engineering,General Physics and Astronomy,Literature and Literary Theory,Linguistics and Language,Language and Linguistics,Psychiatry and Mental health,Clinical Psychology,Development,Geography, Planning and Development,Health Policy,Economics, Econometrics and Finance (miscellaneous),Literature and Literary Theory,Linguistics and Language
Reference17 articles.
1. MIHALALCHE, ROGOVEANU, Immunohistochemical study in colon cancer patients. Current Health Sciences Journal, 2011; Vol.37(3).
2. ATHANASSIOS C. TSAMANDAS, DIMITRIOS KARDAMAKIS, Bcl-2, Bax and p53 expression in rectal adenocarcinoma. Correlation with Classic pathologic prognostic factors and patients outcome. University of Patras Medical School. Greece. 2007; in vivo21:113-118.
3. Azza Hegazy, Sahar A. Daoud, Role of Ki-67, p53 and Bcl-2 in Advanced Colorectal carcinoma (Histopathological and Immunohistochemical Study). Academic Journal of Cancer Research. 2014; 7(3):168-172.
4. Marwan G. Fakih, Metastatic colorectal cancer: Current State and Future Directions, Journal of Clinical Oncology. 2015; 33(16):1809-1824.
5. PETROS C. PAPAGIORGIS, ADAMANTIA. ZIZI, Disparate clinicopathological correlations of p53 and Bcl-2 in colorectal cancer, Molecular medicine reports.2012; 5: 377-382.