ORAL RESVERATROL AS AN ADJUVANT THERAPY IN THE TREATMENT OF MILD TO MODERATE ACNE VULGARIS: A PROSPECTIVE OBSERVATIONAL STUDY

Abstract

Background: Acne vulgaris is an inammatory skin disease usually affecting individuals between 12 and 24 years of age. Many topical and systemic agents are used in the treatment of acne, based on the grade. Complementary and alternative medicine therapies like vitamin C, nicotinamide, zinc, resveratrol, curcumin, etc. are increasing in popularity in the treatment of acne and rosacea. Resveratrol is a natural ingredient that is most abundant in the skin of red grapes, blueberries, boiled peanuts, etc. Resveratrol has considerable anti-inammatory, antioxidant, antiaging, and anti-microbial properties. However, there is a paucity of data regarding the use of oral Resveratrol in the management of acne; hence, this study is undertaken. To study the effectiveness of oral resveratrol as a Aim: n adjuvant therapy in patients with mild to moderate acne vulgaris. Materials And Methods: Forty-six patients diagnosed with mild or moderate acne vulgaris were sampled via consecutive sampling and assigned to two groups, those receiving a combination of topical 1% clindamycin plus 0.1% adapalene and oral resveratrol 50 mg (24) and those receiving topical 1% clindamycin plus 0.1% adapalene (22). Both groups were assessed at weeks 4, 8, and 12 by applying the global acne grading system, and side effects were noted. Both groups showed remarkable responses at weeks 4, 8, a Results And Conclusions: nd 12. However, the Resveratrol group showed an earlier response at weeks 4 and 8, with an early decrease in lesion counts. On intergroup comparison, no signicant difference was found in terms of response rates at week 12. As a result of our ndings, resveratrol appears to be effective as adjuvant therapy in the treatment of acne vulgaris It has the advantage of better tolerability as compared to topical 1% Clindamycin plus 0.1% adapalene