ASSOCIATION OF SERUM ALBUMIN WITH ANTITUBERCULER THERAPY (ATT) INDUCED HEPATOXICITY

Abstract

Background: Anti tuberculosis therapy (ATT) induced liver injury, a common serious adverse drug reaction, is one of the most challenging clinical problems, cause of hospitalization and life- threatening events. Various risk factors have been found to be associated with drug induced hepatitis (DIH) in general population. This study aimed to determine the risk factors, particularly low serum albumin associated with the DIH among the patients of pulmonary and extrapulmonary tuberculosis. In this cross sectional study, 30 patients diagnosed with ATT induced hepatitisMethod: were included and their serum albumin levels were observed. Standard diagnostic criteria were applied for diagnosis of ATT induced hepatitis. Serum albumin levels along with age, gender and alcoholic status of patients with diagnosed DIH were noted. Out of 30 patients studied, 7Result: were females and 23 were males. 19 (63.33%) were ≥ 35 years and 11(36.67%) were <35 years of age. 8 patients had extrapulmonary tuberculosis and 22 patients had pulmonary tuberculosis. Out of 22 patients with pulmonary tuberculosis, 14 (63.64%) patients and out of 8 patients of extrapulmonary tuberculosis, 4 (50%) patients had serum albumin level <3.5 g/dl. Conclusion: Low serum albumin is a risk factor for development of ATT drug induced hepatitis.