STUDY OF THREE MALARIA RAPID DETECTION TESTS AND ITS CORRELATION WITH PARASITIC INDEX FOR P.FALCIPARUM AND P.VIVAX

Author:

Gaikwad Dipti1,Kumar Chaya A.2,Baveja Sujata3

Affiliation:

1. Postgraduate Resident, Department Of Microbiology, Lokmanya Tilak Municipal Medical College And General Hospital, Sion, Mumbai.

2. Associate Professor, Department Of Microbiology, Lokmanya Tilak Municipal Medical College And General Hospital, Sion, Mumbai.

3. Professor And HOD, Department Of Microbiology, Lokmanya Tilak Municipal Medical College And General Hospital, Sion, Mumbai.

Abstract

Objective: To determine the sensitivity and specificity of three Malaria rapid antigen detection tests(RDTs) .To study the sensitivity of the RDTs in relation to parasitic index . Materials and Methods: The study was conducted at a tertiary care hospital. Peripheral smear were prepared and stained.Parasite index was calculated. Three rapid antigen detection tests ; Optimal – IT, Paramax-3 and QDx malaria PAN/PF were tested. Results: Sensitivity for Optimal – IT was highest (98.47%). QDx malaria PAN/Pf gave highest specificity (97%). All the three RDTs gave sensitivity of 100% at a parasitic index of more than 100 parasites per µl. Sensitivity of Optimal – IT and QDx malaria PAN/Pf for P falciparum and P vivax was 100% and 88.88% respectively at a parasitic index of 51-100 parasites/ µl. Conclusion: Malaria RDTs are a good diagnostic tool in health care set ups where quick results are desired and expert microscopy is not available.

Publisher

World Wide Journals

Reference18 articles.

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2. Malaria. http://www.malariasite.com. Accessed on 24. 07. 2010.

3. Chatterjee, K, D., “Parasitology: In relation to clinical medicine”.12th ed. Chatterjee Medical Publishers; 1980.

4. Tangpukdee, N., Duangdee, C., Wilairatana, P., Krudsood, S.,(2009),“ Malaria Diagnosis: ABrief Review”. Korean Journal of Parasitoogy,47(2): 93-102.

5. Coleman,R. E., Sattabangkot, J,, Promstaporm, S., Maneechai, N., Tippayachi, B., Kenglucha, A., et al. (2006), “Comparison of PCR and microscopy for the detection of asymptomatic malaria in a Plasmodium falciparum /vivax endemic area in Thailand.” Malaria Journal ; 5,121.

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