A REVIEW OF DRUG REPROFILING FOR COVID-19: TEICOPLANIN, A POTENTIAL AGENT AGAINST SARS-COV-2

Author:

Kushwaha Saurabh1

Affiliation:

1. Resident (Ophthalmology), Dept of Ophthalmology, Army College of Medical Sciences, Delhi Cantt, New Delhi – 110010

Abstract

COVID-19 caused by Sever Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) rst identied at Wuhan, China has rapidly spread across over 6 continents to become a pandemic and a Public Health Emergency of International Concern (PHEIC). Till date there is no specic drug for the disease. So there is an imminent requirement to identify an effective drug to control the outbreak. A number of COVID-19 cases are reported to be associated with co-bacterial infections especially in immunocompromised individuals. Teicoplanin, a glycopeptide antibiotic, in the past has been reported to possess antiviral efcacy against coronaviruses such as MERS-CoV and SARS-CoV. In a recently conducted in vitro study, it has also been observed to possess antiviral activity against SARS-CoV-2. Here we summarize, Teicoplanin, an antibiotic as a potential therapeutic repurposing option for the treatment of COVID-19, especially in severely ill patients and those having co-bacterial infections.

Publisher

World Wide Journals

Subject

Insect Science,Ecology, Evolution, Behavior and Systematics,Infectious Diseases,Immunology and Allergy,Medicine (miscellaneous),Epidemiology,Molecular Biology,Biochemistry,Infectious Diseases,Pulmonary and Respiratory Medicine,Aerospace Engineering,Mechanical Engineering,Energy Engineering and Power Technology,Aerospace Engineering,Computer Networks and Communications,Software,Electrical and Electronic Engineering,Communication,Artificial Intelligence,Information Systems,Control and Systems Engineering,Software,Urban Studies,Sociology and Political Science,Development

Reference29 articles.

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2. Hui DS, I Azhar E, et al. The continuing 2019-nCoV epidemic threat of novel coronaviruses to global health—The latest 2019 novel coronavirus outbreak in Wuhan, China. Int J Infect Dis. 2020. 91: 264–66.

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4. World Health Organization (WHO) https://covid19.who.int/ . (28 October 2022)

5. Zhou N, Pan T, et al. Glycopeptide Antibiotics Potently Inhibit Cathepsin L in the Late Endosome/Lysosome and Block the Entry of Ebola Virus, Middle East Respiratory Syndrome Coronavirus (MERS-CoV), and Severe Acute Respiratory Syndrome Coronavirus (SARS-CoV). J Biol Chem. 2016.

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