CLINICO-PATHOLOGICAL CORRELATION OF HYSTERECTOMY SPECIMENS

Abstract

Background: Hysterectomy is the most common gynaecological procedure performed worldwide. For centuries, the female reproductive system has been affected by various abnormalities and diseases and hence has been the subject of interest and the basis for the gynaecological practice. The uterus being a vital reproductive and hormone-responsive organ, is subjected to a variety of physiological changes and benign and malignant disorders. Aims and Objectives: To study the indications of hysterectomy, to study gross and histopathological features of uterus and cervix in hysterectomy specimens, correlate with clinical ndings and to identify the most common pathology in hysterectomy specimens. Material and Methods: This was a descriptive study of the gross and histopathological ndings of uterus and cervix in 200 hysterectomy specimens received in the department. The hysterectomy specimens received were xed in 10% formalin for 24 hours, were examined grossly and necessary sections were obtained. The tissue pieces were then processed in automated tissue processor, well labelled parafn blocks were made. Approximately 2-3 thickness sections were cut with the help of microtome and were stained routinely by Hematoxylin & Eosin stain and special stains like PAS or other were used wherever necessary. The histopathological ndings of uterus and cervix were noted and these ndings were then correlated with clinical diagnosis. Results: Overall clinicopathological correlation was noted in all 200 cases. In cases of uterine broid it was 77.77% and 100% in case of endometrial carcinoma, cervical dysplasia and cervical carcinoma. Most common pathology found was uterine leiomyomas in 63 cases and next to it was adenomyosis in 39 cases. Conclusion: This study conrmed that benign diseases were more common in hysterectomy specimens than in their malignant counterparts. It can be concluded that clinico-pathological correlation in case of endometrial cancer and uterine broid is excellent, but in case of DUB and prolapse uterus it varies. This signies the importance of clinico-pathological correlation in all cases of hysterectomy to improve the clinical outcome and post-operative management