HISTOMORPHOLOGICAL DISTRIBUTION AND ENDOSCOPIC CORRELATION OF COLONOSCOPIC BIOPSIES IN RURAL NORTH INDIA

Abstract

Colonoscopy provides information on the natural history and complications of many lesions. Biopsy forceps provide the opportunity to obtain multiple samples for evaluating the pathogenesis of the disease. Pathologist plays an important role in the diagnosis and management of patients with colitis. It is further made use of for GI cancers that are amongst the commonest malignancies worldwide. This prospective study of 300 cases included colonoscopic biopsies received in the department of pathology. We found out of 300 cases, 237 were non-neoplastic, 12 cases were benign and 51 were neoplastic. Out of the non-neoplastic cases, maximum was ulcerative colitis (UC); followed by acute colitis and chronic colitis. The benign lesions included tubular adenoma and tubulo-villous adenoma. Amongst the malignant ones, moderately differentiated adenocarcinomas predominated. On endoscopic histopathological correlation, non neoplastic lesions, benign and malignant lesions correlated 71%, 100% and 88% respectively. Conclusion of the study advocated that comprehensive histopathological study of the colonoscopic biopsy specimens should be done in constant correlation with the clinical and colonoscopic procedures for follow up of inflammatory diseases like UC and CD as well as early recognition of carcinomas.