FORMULATION, OPTIMIZATION AND EVALUATION OF FAST DISSOLVING SUBLINGUAL FILM OF ZIPRASIDONE USING STATISTICAL DESIGN

Abstract

The purpose of this investigation was to formulate, optimize and evaluate sublingual lm for the treatment of schizophrenia and bi polar disorder. Sublingual lms were prepared by solvent casting method. Present investigation 2 were formulated by using HPMC E15 (X ) as polymer and Polyethylene glycol (X ) as plasticizer were chosen as independent variables in 3 full 1 2 factorial design while Tensile strength (TS), Disintegration time (DT) and % Cumulative drug release at 10 min. (% CDR) were taken as dependent variables. The various physical parameters were evaluated for sublingual lms such as thickness, tensile strength, folding endurance, disintegration time, surface pH and % CDR. From the experimental study, it was concluded that the optimized batch ZSF showed 98.4 %, the 4 highest release of the drug. Stability study was performed by taking an optimized formulation and it was observed stable. The sublingual lms 2 showed acceptable results in all studies. 3 full factorial design was successfully applied during preparation, optimization and evaluation of sublingual lms of Ziprasidone. The present investigation showed quick disintegration and fast release of the drug for the treatment of schizophrenia and bi polar disorder.