COMPARISON ON VALUES OF MMP-2 AND PRO-BNP TO IDENTIFY THE RISK OF ACUTE MYOCARDIAL INFARCTION IN PATIENTS WITH DIABETES MELLITUS

Abstract

Introduction: The present study has been planned to assess the levels of MMP-2 and Pro-BNP in patients suffering with Diabetes mellitus. the study showed that levels of above said inammatory biomarkers at different time intervals and it was rst to report the levels of biomarkers in AMI patients with DM. Material And Methods: 86 patients were selected and divided into two groups, Group A included 43 healthy volunteers, Group B included patients with DM and suffering from AMI. Blood concentration of biochemical parameters related to AMI was assessed at the baseline and levels of MMP-2 and Pro-BNP were assessed via ELISA kits at 0th , 30th ,60th and 90th day of the enrolment of DM patients with AMI. Results: Assessment of biochemical parameters were done and found signicantly increased levels was found in group B as compared to group A. Among the DM patients with AMI (conrmed as per guidelines) in group B, MMP-2 and Pro-BNP levels were found signicantly decreased on 0th day to 30th day (P=5.28E-16 and P=1.5E-22), 30th day to 60th day (P=1.04E-07and P=1.2E-30)and 60th day to 90th day (P=5.37E-05 and P=1.66E-12) respectively. Plasma levels of Pro-BNP and MMP-2 were correlated and Pro-BNP levels were still found signicantly increased on the 90th day of enrolment of DM patients. Discussion Time dependent relationships were found in Pro-BNP and MMP-2 serum levels, therefore these biomarkers were directly correlated with AMI. At 90th day, Pro-BNP levels were found signicantly increased as compared to healthy volunteers of group A.