STUDY OF PLEURAL FLUID TO SERUM CHOLINESTERASE RATIO TO DIFFERENTIATE BETWEEN TRANSUDATE AND EXUDATE AND ITS CORRELATION WITH LIGHT'S CRITERIA-Reference-Cited by-同舟云学术

STUDY OF PLEURAL FLUID TO SERUM CHOLINESTERASE RATIO TO DIFFERENTIATE BETWEEN TRANSUDATE AND EXUDATE AND ITS CORRELATION WITH LIGHT'S CRITERIA

Published:2020-11-01 Issue: Volume: Page:29-31
ISSN:
Container-title:INDIAN JOURNAL OF APPLIED RESEARCH
language:en
Short-container-title:IJAR

Author:

MR Manohar¹,Shetty Deepti²,VM Vikram³

Affiliation:

1. Assistant Professor, Department of Medicine, AIMS, BG Nagar.

2. Senior Resident, Department of Paediatrics, AIMS, BG Nagar.

3. Assistant Professor, Department of Medicine, SSMC, Davangere.

Abstract

Background: Pleural effusion is a common clinical condition faced in everyday practice. The first step in the management of pleural effusion is its differentiation into transudates and exudates. Light’s criteria is the most widely used parameter to differentiate pleural effusions but studies have shown that Light’s criteria misclassifies a significant amount of cases. Methods: Study included 125 patients who had pleural effusion who met the inclusion and exclusion criteria. Duration of the study was 12 months. Results: Accordingly the mean value of this ratio was 0.10 + 0.05 in the transudates group and 0.39 + 0.14 in the exudates group. This difference was found to be statistically significant (p-value < 0.001). This ratio misclassified 5 cases. Among them 2 (3.2%) were transudates that were misdiagnosed as exudates and 3 (4.8%) were exudates that were misdiagnosed as transudates.In this study Light’s criteria misclassified 13 cases in total with a sensitivity of 91.9% and a specificity of 87.3%. Conclusions: Light’s criteria has a good sensitivity and specificity but P/S ChE was the most efficient parameter in differentiating between transudates and exudates in this study.

Publisher

World Wide Journals

Reference14 articles.

1. Malyse ML. Non-Malignant Pleural Effusions. In: Fishman AP, Elias JA, Fishman JA, Grippi MA, Senior RM, Pack AI, editors. Fishman’s Pulmonary Diseases and Disorders. 4th ed. Vol 2. New York: McGraw Hill; 2008. p. 1487.

2. Light RW, McGregor MI, Luchsinger PC. "Pleural effusion: The diagnostic separation of transudates and exudates". Ann Intern Med 1972; 77:507-8

3. Light RW. Disorders of the pleura. In: Kasper DL, Fauci AS, Hauser SL, Longo DL, Jameson JL, Loscalzo J, editors. Harrison’s principles of Internal Medicine. 19th ed. Vol 2. New York: McGraw Hill; 2015. p. 1716.

4. Reechaipichitkul W, Kawamatawong T, Teerajetgul Y, Patjanasoontorn B. Diagnostic role of pleural fluid adenosine deaminase in tuberculous pleural effusion. Southeast Asian J Trop Med Public Health 2001;32:383-9.

5. Sharma SK, Suresh V, Mohan A, Kaur P, Saha P, Kumar A, Pande JN. A prospective study of sensitivity and specificity of adenosine deaminase estimation in the diagnosis of tuberculosis pleural effusion. Indian J Chest Dis Allied Sci 2001;43:149-55.