A COMPARISION OF FENTANYL AND NALBUPHINE IN ATTENUATING HAEMODYNAMIC RESPONSE TO DIRECT LARYNGOSCOPY AND ENDOTRACHEAL INTUBATION- A STUDY OF 90 CASES

Abstract

BACKGROUND- Laryngoscopy and endotracheal intubation is known to cause hemodynamic changes which are usually increase in heart rate and blood pressure.Various drugslike beta blockers,opioids and alpha 2 agonists have been tried to attenuate these hemodynamic responses. AIMS-To compare the effects of Fentanyl and Nalbuphine in attenuating the stress response to directlaryngoscopy and endotracheal intubation. METHODS- After informed consent we studied 90patients,all posted for surgery under general anaesthesia between the age group of 15 to 60. We conducted the study over a period of 6months. Data was collected and analysed. Three groups of patients were made Group A – Inj. Fentanyl 2µg/kg ivGroup B– Inj. Nalbuphine 0.2mg/kg ivGroup C- Inj Normal Saline 10cc. Only ASA I and II patients were included in the study.Haemodynamic changes were noted by meticulous monitoring and analyzed. RESULTS-The hemodynamic stress response to laryngoscopy and endotracheal intubation in the form of increased heart rate,systolic blood pressure,diastolic blood pressure and mean blood pressure were less with Fentanyl as compared to Nalbuphine and Normal Saline.CONCLUSION-Fentanyl is more effective than Nalbuphine in attenuating hemodynamic stress response tolaryngoscopy and endotracheal intubation.