“ASSESSMENT OF SERUM BIOMARKERS WITH TREATMENT OUTCOME AMONG PATIENTS WITH IDIOPATHIC PARKINSON'S DISEASE IN A TERTIARY CARE HOSPITAL, KOLKATA”

Abstract

Obectives: There is a pressing need for robust diagnostic & prognostic biomarkers in idiopathic Parkinson's disease. So far most of potential biomarkers have been studied in isolation.No study has yet been done taking all the biomarkers into consideration. Our study thus aimed to investigate the diagnostic & prognostic potential of a panel of biomarkers in IPD patients of West Bengal. Methods: 55 untreated patients of clinically diagnosed idiopathic Parkinson's disease within the age group 50 – 80 years visiting in the neurology out-patient department of R. G. Kar Medical College and Hospital, were taken as cases , included in the study, based on a set of xed inclusion & exclusion criteria. Serum TSH, fT3 ,Uric acid, Homocysteine were measured in diagnosed untreated cases and 3& 6 months post treated cases of Idiopathic Parkinson's disease. Also correlation of above-mentioned biomarkers with disease seveirity ( UPDRS 2) were also assayed. Thin layer chromatography was done with aromatic amino acids( Phenylalanine, Tyrosine and Tryptophan) in untreated cases of IPD as well as 3 & 6 months post treated too. Results: The results of statistical analysis showed that levels of serum Uric acid ( P value < 0.0001) and serum homocysteine ( P value= 0.0003) were signicantly raised in patients of IPD compared to their apparently healthy age and sex matched controls .We also found signicantly raised value of serum level of TSH ( P <0.0001) &Uric acid ( P value < 0.0.0001) and signicantly lowered value of serum fT3 ( P < 0.0001) in 3 months and 6 months post treated cases compared to untreated cases of IPD.A Signicant correlation was found between serum levels of fT3(P value= 0.0344, Pearson r= 0.2857) with disease severity(UPDRS 2) of IPD. Interpretation: Serum Uric acid and Homocysteine level is associated with increase risk factor of IPD . Serum TSH ,Uric acid and fT3would be a better upcoming diagnostic and prognostic marker for diagnosis of IPD patients .