Papiller Tiroid Karsinomada Tümör Büyüklüğü ve Metastazın Belirticisi Olarak Nötrofil Lenfosit Oranı

Abstract

Aim: Inflammation plays a critical role in many cancer features such as tumor development and progression. Recently, the neutrophil-lymphocyte ratio (NLR) has been evaluated as a simple and valid systematic marker of inflammatory response. The aim of this study was to investigate the prognostic value of the preoperative neutrophil / lymphocyte ratio. Material and Methods: In this study, archive files of 259 adult cases were evaluated retrospectively. Kolmogorov Smirnov test, Mann Whitney U Test, Kruskal Wallis and Dunn multiple comparison tests were used in the statistical analysis. Results: A statistical correlation was found between the neutrophil/lymphocyte ratio and T staging, lymph node and distant metastases (p2.0906>1,644, the sensitivity to predict papillary thyroid cancers larger than 1 cm, lymph node metastasis and distant metastasis was found to be 85.4%, 73.8%, and 96% respectively. Conclusion: Neutrophil/lymphocyte ratio is associated with tumor size and presence of metastasis. The neutrophil/lymphocyte ratio may help us predict the size of the tumor, lymph node involvement, and distant metastasis when the right cut-off points are established.