Affiliation:
1. Muş Alparslan Üniversitesi
Abstract
Geranium tuberosum roots are consumed fresh in some areas of the countryside of Turkey. This study was conducted to scientifically validate the traditional use of the species. The enzyme inhibition effect and antimicrobial activity of the root and leaf parts of Geranium tuberosum were investigated using a methanol extract. The leaf extract had higher acetylcholinesterase and butyrylcholinesterase activity than the root extract, while the root extract showed a stronger inhibitory effect on xanthine oxidase enzyme.. Also, the antifungal and antibacterial activities of the extracts were investigated using the hollow agar technique. It was observed that both extracts gave high antimicrobial activity on different bacterial strains. These results confirmed that Geranium tuberosum is a natural antibacterial, and has enzyme inhibitory potential.
Reference39 articles.
1. Almaz, Z. (2023). Investigation of biological activities of various 1, 2, 3‐triazole compounds: Their effects on cholinesterase enzymes, determination of antioxidant capacity and antimicrobial activity. Journal of Biochemical and Molecular Toxicology, 37(3), e23277.
2. Almaz, Z., Oztekin, A., Tan, A., & Ozdemir, H. (2021). Biological evaluation and molecular docking studies of 4-aminobenzohydrazide derivatives as cholinesterase inhibitors. Journal of Molecular Structure, 1244, 130918.
3. Anil, D. A., Aydin, B. O., Demir, Y., & Turkmenoglu, B. (2022). Design, synthesis, biological evaluation and molecular docking studies of novel 1H-1, 2, 3-Triazole derivatives as potent inhibitors of carbonic anhydrase, acetylcholinesterase and aldose reductase. Journal of Molecular Structure, 1257, 132613.
4. Aras, A., Bursal, E., Alan, Y., Turkan, F., Alkan, H., & Kılıç, Ö. (2018). Polyphenolic content, antioxidant potential and antimicrobial activity of Satureja boissieri. Iranian Journal of Chemistry and Chemical Engineering, 37(6), 209-219.
5. Bayrak, S., Öztürk, C., Demir, Y., Alım, Z., & Küfrevioglu, Ö. İ. (2020). Purification of polyphenol oxidase from potato and investigation of the inhibitory effects of phenolic acids on enzyme activity. Protein and peptide letters, 27(3), 187-192.