Nickel-catalyzed alkene <i>ipso</i>-selective reductive hydroamination with nitroarenes

Abstract

Aromatic amine synthesis via reductive coupling between alkenes and nitroarenes is attractive; however, it remains underdeveloped. Herein, we report a nickel-catalyzed alkene hydroamination with nitroarenes under mild reductive conditions. This reaction exhibited an <i>ipso</i>-selectivity and enabled repaid preparation of aromatic amines with primary and secondary alkyl groups. Many functional groups were well tolerated, providing an efficient approach for drug-like arylamine synthesis.