Linkage Analyses of the MODY3 Locus on Chromosome 12q With Late-Onset NIDDM

Author:

Lesage Suzanne1,Hani El Habib1,Philippi Anne1,Vaxillaire Martine1,Hager Jörg1,Passa Philippe2,Demenais Florence3,Froguel Philippe1,Vionnet Nathalie13

Affiliation:

1. Centre National de la Recherche Scientiflque EP10, Institut Pasteur and University Hospital Lille

2. Service d'Endocrinologie, Hôpital Saint-Louis Paris, France

3. Institut National de la Sante et de la Recherche Medicale U358, Hôpital Saint-Louis Paris, France

Abstract

Non-insulin-dependent diabetes mellitus (NIDDM) is a clinically and genetically heterogeneous disorder. Maturity-onset diabetes of the young (MODY), an autosomal dominant form of NIDDM, has been used as a model for genetic studies of NIDDM. We recently reported linkage between markers on chromosome 12q and diabetes in 25% of our French MODY families. To evaluate if this gene is also implicated in late-onset NIDDM, we performed linkage studies between two markers of the MODY region and diabetes in 172 families with late-onset NIDDM. Both parametric and nonparametric methods were used in a total of 600 affected sib-pairs. Linkage was rejected in this population by all methods, implying that the MODY gene on chromosome 12q is not a major gene for late-onset NIDDM in this population. However, we cannot exclude a modifying role in a polygenic disorder or an important role in some families.

Publisher

American Diabetes Association

Subject

Endocrinology, Diabetes and Metabolism,Internal Medicine

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