Localization of MODY3 to a 5-cM Region of Human Chromosome 12-Reference-Cited by-同舟云学术

Localization of MODY3 to a 5-cM Region of Human Chromosome 12

Published:1995-12-01 Issue:12 Volume:44 Page:1408-1413
ISSN:0012-1797
Container-title:Diabetes
language:en
Short-container-title:

Author:

Menzel Stephan¹,Yamagata Kazuya¹,Trabb Jeffrey B¹,Nerup Jørn²,Permutt M Alan³,Fajans Stefan S⁴,Menzel Ruth⁵,Iwasaki Naoko⁶,Omori Yasue⁶,Cox Nancy J¹,Bell Graeme I¹

Affiliation:

1. Howard Hughes Medical Institute and Departments of Biochemistry and Molecular Biology and Medicine, The University of Chicago Chicago, Illinois

2. Steno Diabetes Center Gentofte, Denmark

3. Division of Endocrinology, Diabetes, and Metabolism, Department of Internal Medicine, Washington University School of Medicine St. Louis, Missouri

4. Division of Endocrinology and Metabolism, Department of Internal Medicine, The University of Michigan Ann Arbor, Michigan

5. Clinic for Diabetes and Metabolic Diseases Karlsburg, Germany

6. Diabetes Center, Tokyo Women's Medical College Tokyo, Japan

Abstract

Maturity-onset diabetes of the young (MODY) is a heterogeneous disorder that appears to be characterized by a primary defect in insulin secretion. Mutations in an unknown locus (MODY1) on chromosome 20 and the glucokinase gene (MODY2) on chromosome 7 can cause this form of non-insulin-dependent diabetes. Recent genetic studies have identified a third locus on chromosome 12 (MODY3) that is linked to MODY in a group of French families. We have identified three families from Denmark, Germany, and the U.S. (Michigan) showing evidence of linkage with MODY3 and a family from Japan showing suggestive evidence. Analysis of key recombinants in these families localized MODY3 to a 5-cM interval between the markers D12S86 and D12S807/D12S820.

Publisher

American Diabetes Association

Subject

Endocrinology, Diabetes and Metabolism,Internal Medicine

Link

https://journals.org/diabetes/diabetes/article-pdf/44/12/1408/361017/44-12-1408.pdf

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