The Insulin Gene Promoter: A Simplified Nomenclature

Author:

German Michael1,Ashcroft Stephen2,Docherty Kevin3,Edlund Helena4,Edlund Thomas4,Goodison Steven2,Imura Hiroo5,Kennedy Giulia6,Madsen Ole7,Melloul Danielle8,Moss Larry9,Olson Karl10,Permutt M Alan11,Philippe Jacques12,Robertson R Paul10,Rutter William J1,Serup Palle7,Stein Roland13,Steiner Donald14,Tsai Ming-Jer15,Walker Michael D16

Affiliation:

1. University of California San Francisco, CA

2. John Radcliffe Hospital Oxford, U.K.

3. University of Aberdeen Aberdeen, Scotland

4. University of Umea Umea, Sweden

5. Kyoto University Kyoto, Japan

6. Millenium Pharmaceuticals Cambridge, MA

7. Hagedorn Research Institute Copenhagen, Denmark

8. Hebrew University Jerusalem, Israel

9. Tufts Medical School Boston, MA

10. University of Minnesota Minneapolis, MN

11. Washington University St. Louis, MO

12. University of Geneva Geneva, Switzerland

13. Vanderbilt University School of Medicine Nashville, TN

14. University of Chicago Chicago, IL

15. Baylor College of Medicine Houston, TX

16. Weizmann Institute of Science Rehovot, Israel

Abstract

The tools of molecular biology have rapidly expanded our knowledge of how β-cells regulate insulin gene expression. As this work has progressed in parallel in different laboratories, alternate nomenclature systems have been developed to describe the functionally important elements of the insulin gene. This jumble of names is confusing to those outside the field and intimidating to neophytes. Therefore, we have agreed to a simple, uniform set of names for the major insulin gene promoter elements.

Publisher

American Diabetes Association

Subject

Endocrinology, Diabetes and Metabolism,Internal Medicine

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