Polymorphic Human Glucose Transporter Gene (GLUT) is on Chromosome 1p31.3→p35

Author:

Shows Thomas B1,Eddy Roger L1,Byers Mary G,Fukushima Yoshimitsu1,Dehaven Catherine R2,Murray Jeffrey C2,Bell Graeme I3

Affiliation:

1. Department of Human Genetics, Roswell Park Memorial Institute, New York State Department of Health Buffalo, New York

2. Department of Pediatrics, The University of Iowa Iowa City, Iowa

3. Howard Hughes Medical Institute and the Department of Biochemistry and Molecular Biology, The University of Chicago Chicago, Illinois

Abstract

The glucose transporter is a membrane glycoprotein that is involved in the uptake of glucose by most, if not all, animal cells. A cloned cDNA that encodes the human protein was used to map the gene to a specific chromosomal region and to identify a DNA polymorphism. The human gene (designated GLUT) was assigned to chromosome 1p31.3H→p35 by hybridization of the probe to DNA from a panel of human-mouse somatic cell hybrids containing different human chromosomes and by in situ hybridization to isolated metaphase chromosomes. The most likely location of GLUT is in 1p33. A common two-allele restriction-fragment-length polymorphism was identified with Xba I. Diabetes.

Publisher

American Diabetes Association

Subject

Endocrinology, Diabetes and Metabolism,Internal Medicine

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