Finerenone in Patients With Chronic Kidney Disease and Type 2 Diabetes by Sodium–Glucose Cotransporter 2 Inhibitor Treatment: The FIDELITY Analysis
Author:
Rossing Peter12ORCID, Anker Stefan D.3, Filippatos Gerasimos4, Pitt Bertram5, Ruilope Luis M.678, Birkenfeld Andreas L.910, McGill Janet B.11, Rosas Sylvia E.1213ORCID, Joseph Amer14, Gebel Martin15, Roberts Luke16, Scheerer Markus F.17, Bakris George L.18ORCID, Agarwal Rajiv19, Aizenberg Diego, Bartolacci Inés, Besada Diego, Bittar Julio, Chahin Mariano, Elbert Alicia, Gelersztein Elizabeth, Liberman Alberto, Maffei Laura, Pérez Manghi Federico, Sanabria Hugo, Vallejos Augusto, Viñes Gloria, Wassermann Alfredo, Abhayaratna Walter, Acharya Shamasunder, Ekinci Elif, Lee Darren, MacIsaac Richard, Mann Mah Peak, Nelson Craig, Packham David, Pape Alexia, Roger Simon, Stephenson Hugo, Suranyi Michael, Wittert Gary, Vale Elizabeth, Colman Peter, Colquhoun David, Ellis Chris, Joshua Kim, Pedagogos Eugenia, Regal Paul, Topliss Duncan, Vandeleur James, Verjans Johan, Wittert Gary, Wynne Katie-Jane, Clodi Martin, Ebenbichler Christoph, Fliesser-Görzer Evelyn, Hanusch Ursula, Krebs Michael, Lhotta Karl, Ludvik Bernhard, Mayer Gert, Neudorfer Peter, Paulweber Bernhard, Prager Rudolf, Preiß Wolfgang, Prischl Friedrich, Schernthaner Gerit-Holger, Sourij Harald, Wiesholzer Martin, Drexel Heinz, Oberbauer Rainer, Schönherr Hans-Robert, Doubel Peter, Engelen Wendy, Gillard Pieter, Hougardy Jean-Michel, Krzesinski Jean-Marie, Maes Bart, Speeckaert Marijn, Stas Koen, van Gaal Luc, Vanbelleghem Hilde, Duyck Francis, Scheen André, Antunes Daniela, Botelho Roberto, Brito Claudia, Canani Luis, Canziani Maria Eugenia, Cerqueira Maria, de Paula Rogerio, Eliaschewitz Freddy, Figueiredo Carlos Eduardo, Forti Adriana, Hissa Miguel, Leite Maurilo, Lima Emerson, Noronha Irene, Paolino Bruno, Paschoalin Nathalia, Paschoalin Raphael, Pecoits Filho Roberto, Pereira Marcio, Portes Evandro, Precoma Dalton, Rea Rosangela, Riella Miguel, Salles Joao Eduardo, Vasconcellos Eduardo, Vencio Sergio, Bacci Marcelo, Maia Lilia, Villacorta Aline, Apostolova Emiliya, Boshnyashka Radostina, Farah Ghassan, Georgiev Dimitar, Gushterova Valentina, Klyuchkova Neli, Lucheva Mariya, Manova Petya, Minkova Dotska, Nonchev Boyan, Pichmanova Mariyana, Prakova Zhulieta, Rangelov Rangel, Rashkov Rosen, Stanchev Pavel, Stoyanovska-Elencheva Bilyana, Tagarev Zhivko, Temelkova-Kurktschieva Theodora, Vasileva Svetla, Yoncheva-Mihaylova Mariana, Marinchev Angel, Miteva Mariya, Barre Paul, Carlson Brian, Conway James, Cournoyer Serge, Dumas Richard, Fikry Sameh, Goluch Richard, Hamet Pavel, Hart Randolph, Henein Sam, Liutkus Joanne, Madore Francois, Martinho Valdemar, Mazza Giuseppe, McFarlane Philip, O’Keefe Dennis, Peterson Sean, Schwartz Daniel, Shu Daniel, Steele Andrew, Tellier Guy, Tennankore Karthik, Tobe Sheldon, Tsoukas George, Tytus Richard, Vitou Louise, Walsh Michael, Weisnagel Stanley, Wilderman Igor, Yale Jean-Francois, El Boreky Fadia, Kelly Alan, Leiter Lawrence, Teitelbaum Ivor, Cobos Jorge, Godoy Juan, González Fernando, Lobos Sergio, Palma Juan Carlos, Prieto Dominguez Juan Carlos, Reyes Eliana, Romero Carmen, Saavedra Victor, Vega Mario, Medina Marcelo, Varleta Paola, Bu Ruifang, Cai Hanqing, Chen Nan, Chen Qinkai, Chen Dejun, Cheng Jinluo, Dong Youping, Dong Junwu, Guan Tianjun, Hao Chuanming, Huang Wen, Jiang Fangfang, Lei Minxiang, Li Ling, Li Zhonghe, Li Xuemei, Li Jingmei, Li Yan, Liang Xinling, Liang Bo, Liu Fang, Liu Yinghong, Liu Yuantao, Liu Zhihong, Long Gang, Lu Guoyuan, Lu Weiping, Lu Yibing, Luo Ping, Ma Jianhua, Mo Zhaohui, Niu Jianying, Peng Ai, Shen Jiansong, Shen Feixia, Shi Bingyin, Su Qing, Sun Zhuxing, Tang Shuifu, Tong Nanwei, Wang Hao, Wang Xinjun, Wang Guixia, Wang Jianqin, Wang Yangang, Wang Li, Wei Jiali, Wu Tianfeng, Wu Chaoqing, Xing Changying, Xiong Fei, Xu Xudong, Xu Ning, Yan Tiekun, Yang Jinkui, Yin Aiping, Zeng Longyi, Zhang Hao, Zhang Yanlin, Zhang Ying, Zhao Wenjing, Zhao Zhiquan, Zheng Hongguang, Zhong Ling, Zhu Dalong, Zhuang Yongze, Du Yuming, Fang Yi, Guo Weiying, Jiang Sheng, Kuang Jian, Li Dongmei, Li Hongmei, Li Yinan, Li Yuxiu, Liu Jian, Liu Yu, Miao Heng, Peng Wen, Wang Lihua, Xu Mingtong, Zhong Liyong, Zhu Jun, Arango Clara, Barrera Sandra, Beltrán López Nelly, Benitez Diego, Blanco Guillermo, Cadena Andrés, Coronel Julian, Cure Carlos, Durán Carlos, González Alexander, Guzmán Gustavo, Hernández Eric, Ibarra Jaime, Jaramillo Carlos, Jaramillo Nicolás, Kattah William, Molina Dora, Sánchez Gregorio, Terront Mónica, Trujillo Freddy, Urina Miguel, Vargas Ruben, Villegas Iván, Yupanqui Hernán, Arcos Edgar, Aroca Gustavo, Barreto Germán, Bermudez Andres, Botero Rodrigo, Cárdenas Tatiana, Figueroa Wilmer, Jaramillo Mónica, Liévano Manuel, López Mónica, Molina Dora, Rosero Ricardo, Trillos Pedro, Alferi Dino, Brada Michal, Brezina Jiri, Bucek Petr, Edelsberger Tomas, Gulakova Drahomira, Hasalova Zapletalova Jitka, Hola Olga, Hornova Lucie, Houdova Jana, Hrmova Helena, Karasek David, Kopecka Sarka, Kovar Richard, Krcova Eva, Kuchar Jiri, Kutejova Vlasta, Lubanda Hana, Matyasek Ivo, Mokrejsova Magdalena, Okenka Libor, Prazny Martin, Pumprla Jiri, Tomanek Pavel, Andersen Ulla, Andries Alin, Bech Jesper, Faber Jens, Gislason Gunnar, Hangaard Jørgen, Jaroslaw Pacyk Grzegorz, Juhl Claus, Krarup Thure, Lindhardt Morten, Madsbad Sten, Nielsen Joan, Pedersen-Bjergaard Ulrik, Poulsen Per, Rasmussen Ole, Rossing Peter, Schousboe Karoline, Gram Jeppe, Lauridsen Thomas, Pedersen Erling, Thorsteinsson Birger, Flöjt Päivi, Honkasalo Mikko, Honkasalo Mikko, Humaloja Kari, Kananen Kristiina, Kantola Ilkka, Koistinen Arvo, Korsoff Pirkko, Lahtela Jorma, Nieminen Sakari, Nieminen Tuomo, Sadeharju Karita, Strand Jorma, Sulosaari Sakari, Cariou Bertrand, Chantrel François, Clavel Sylvaine, Combe Christian, Fauvel Jean-Pierre, Gallouj Karim, Gouet Didier, Guerci Bruno, Guerrot Dominique, Hourmant Maryvonne, Klein Alexandre, Mariat Christophe, Marre Michel, Mesbah Rafik, Le Meur Yannick, Monier Arnaud, Moranne Olivier, Roussel Ronan, Serusclat Pierre, Vendrely Benoit, Verges Bruno, Zaoui Philippe, Axthelm Christoph, Bergmann Andreas, Birkenfeld Andreas L., Braun Hermann, Busch Klaus, Contzen Christel, Degenhardt Stefan, Derwahl Karl, Giebel Thomas, Hagenow Andreas, Haller Hermann, Hasslacher Christoph, Horacek Thomas, Jungmair Wolfgang, Kloos Christof, Koch Thorsten, Krüger Thilo, Mühlfeld Anja, Müller Joachim, Pfützner Andreas, Pistrosch Frank, Rinke Andrea, Rose Ludger, Rump Lars, Schettler Volker, Schiefke Ingolf, Schlichthaar Heike, Schröppel Bernd, Schöll Norbert, Schubert Kristin, Schürholz Thomas, Sigal Helena, Stemler Lutz, Strack Georg, Täschner Heidrun, Toursarkissian Nicole, Tschöpe Diethelm, Ulmer Achim, van der Giet Markus, Wanner Christoph, Winkelmann Bernhard R., Boletis Ioannis, Dimitriadis George, Hatziagelaki Erifili, Iatrou Christos, Ioannidis Ioannis, Kounadi Theodora, Makriniotou Ioanna, Papadopoulou Dorothea, Papagianni Aikaterini, Passadakis Ploumis, Piaditis George, Stefanidis Ioannis, Pang Ip Tai, Lee Paul, Luk On Yan Andrea, Ma Ronald, Chow Wing Sun, Wang Angela, Yeung Vincent, Bajcsi Dora, Danos Peter, Harcsa Eleonora, Kalina Akos, Kazup Szilvia, Keltai Katalin, Kirschner Robert, Kiss Julianna, Kovacs Laszlo, Lamboy Beata, Literati-Nagy Botond, Mileder Margit, Nagy Laszlo, Noori Ebrahim, Nyirati Gabor, Petro Gizella, Schneider Karoly, Simon Judit, Szocs Albert, Vasas Szilard, Wudi Krisztina, Zilahi Zsolt, Zsom Marianna, Eustace Joe, Holian John, Reddan Donal, O’Meara Yvonne, Abramof Ness Rosane, Adawi Faiad, Armaly Zaher, Atar Shaul, Bashkin Amir, Ben Chetrit Sydney, Berar Yanay Noa, Chernin Gil, Darawsha Mahmud, Efrati Shai, Elias Mazen, Farber Evgeny, Glandt Mariela, Grossman Ehud, Halabi Majdi, Harman-Boehm Ilana, Khazim Khaled, Liberty Idit, Minuchin Oscar, Mosenzon Ofri, Nakhoul Farid, Nimer Assy, Schwartz Doron, Wainstein Julio, Yagil Yoram, Zukermann Robert, Avogaro Angelo, Battaglia Giovanni Giorgio, Tiziano Bevilacqua Maurizio, Bonora Enzo, Bossi Carlo Antonio, Calabrò Paolo, Cavalot Franco Luigi, Cimino Roberto, Gennaro Cozzolino Mario, David Salvatore, Emdin Michele, Fiaccadori Enrico, Fiorina Paolo, Giorda Carlo Bruno, Gregorini Maria Cristina, La Manna Gaetano, Maggi Davide Carlo, Manti Roberta, Meregalli Giancarla, Pani Antonello, Parvanova Aneliy Ilieva, Perico Norberto, Piatti PierMarco, Pisani Antonio, Pontiroli Antonio Ettore, Ponzani Paola, Santorelli Gennaro, Santoro Domenico, Scanziani Renzo, Teatini Ugo, Tonolo Giancarlo, Trevisan Roberto, Veronelli Anna Maria, Viviani Giorgio Luciano, Araki Hideo, Bando Yukihiro, Ebisui Osamu, Fujita Naruhiro, Fukasawa Hirotaka, Furuya Ryuichi, Hamamoto Yoshiyuki, Hamasaki Akihiro, Hasegawa Kotaro, Hatazaki Masahiro, Hayashi Terumasa, Higashi Takayuki, Hirohata Yoshihide, Horinouchi Shuji, Hoshi Ayumu, Imoto Hirofumi, Inagaki Akemi, Inagaki Masayuki, Inaguma Daijo, Inoue Toshihiko, Ishii Masao, Ishiko Tamayo, Isono Motohide, Jinnouchi Hideaki, Kanai Hidetoshi, Kanda Daisuke, Kanehara Hideo, Kashima Masayuki, Kataoka Yuko, Katayama Shigehiro, Kato Kiyoe, Katsuki Takeshi, Kawamitsu Katsunori, Kawasaki Satsuki, Kikuchi Fumi, Kikuchi Hidetoshi, Kishimoto Rui, Kobayashi Kunihisa, Koide Junko, Komi Rieko, Kubota Miyuki, Kuriya Genpei, Kurose Takeshi, Kusano Yoshiro, Maeda Hajime, Matsubayashi Sunao, Matsumoto Kazunari, Matsumura Naoya, Matsuo Yasuto, Matsuoka Naoki, Miyaoka Hiroaki, Miyata Satoshi, Morita Takeshi, Murakami Isao, Murao Satoshi, Nakamura Udai, Nakayama Mikihiro, Nakazawa Jun, Nohara Sakae, Nomiyama Takashi, Noritake Masayuki, Oda Yoshiaki, Ogiwara Takayuki, Ohashi Hiroshi, Okamoto Hideki, Okino Shinichi, Osonoi Takeshi, Sasaki Nobuhiro, Sayo Yoshitaka, Sekigami Taiji, Shibasaki Taro, Shibata Hirotaka, Shimoyama Tatsushi, Shinoda Junji, Sobajima Hiroshi, Sugitatsu Kazuya, Sugiura Toshiyuki, Sugiyama Toru, Suzuki Daisuke, Suzuki Hiroyuki, Suzuki Masaaki, Takeda Asami, Tanaka Asami, Tanaka Seiichi, Tsunematsu Izumi, Ueda Yasuo, Uekihara Soichi, Ujihara Makoto, Yajima Ken, Yamada Daishiro, Yamada Masayo, Yamagata Kazuo, Yamakawa Ken, Yamakawa Fumiko, Yamasaki Yoshimitsu, Yambe Yuko, Yanagida Taihei, Yanai Hidekatsu, Yanase Toshihiko, Yasuda Tetsuyuki, Kriauciuniene Dovile, Lasiene Jurate, Navickas Antanas, Radzeviciene Lina, Urbanaviciene Egle, Urbonas Gediminas, Velaviciene Audrone, Abd Ghani Rohana, Azizah Aziz Nor, Lee Li Yuan, Loh Chek Loong, Mohd Ali Norhaliza, Mohd Noor Nurain, Nur Fatnoon Nik, Ahmad Nik, Ratnasingam Jeyakantha, Hasnul Wan, Bin Wan Hasan Halimi, Mohd Izani Wan, Mohamed Wan, Najme Khir Rizmy, Mohamad Masni, Tan Tong Boon Alexander, Avila Pardo Sandro, Bastidas Adrian Miriam, Wong Alfredo Chew, Escobedo de la Peña Jorge, Fanghänel Salmón Guillermo, González Gálvez Guillermo, Gutiérrez Ochoa Ramiro, Irizar Santana Saúl, Madero Rovalo Magdalena, Méndez Machado Gustavo, Nevarez Ruiz Luis, Ramos Ibarra Denisse, Ramos López Gabriel, Sauque Reyna Leobardo, Solache Ortiz Gustavo, Valdez Ortiz Rafael, Villagordoa Mesa Juan, Alpizar Salazar Melchor, García Hernández Pedro, González José, Lazcano Soto José, Saldaña Mendoza Arturo, Irizar Santana Sergio, González Vilchis Elvira, Bakker R.C., Barendregt J.N.M., Boonstra A.H., Bos Willem, Brouwer C.B., van Buren M., Gansevoort Ron, Kooy Adriaan, Krekels Marielle, van Leendert Ruud J.M., Lieverse Louis A.G., Luik P.T., Penne E. Lars, Smak Gregoor Peter, Vogt Liffert, van den Born Bert-Jan, Baker John, Crawford Veronica, Cutfield Rick, Dunn Peter, Krebs Jeremy, Nirmalaraj Kingsley, Scott Russell, Smuts Nine, Titchener Janet, Eriksen Erik, Finnes Trine, Høivik Hans, Karlsson Thomas, Munk Peter Scott, Radtke Maria, Risberg Knut, Rocke Jan, Solnør Leidulv, Stenehjem Aud-Eldrid, Tafjord Anne-Beathe, Asprusten Emil, Hagemeier Robert, Høye Kjetil, Selsås Hilde, Thorup Frode, Wium Cecilie, Pamugas Glenda, Panelo Araceli, Perez Ronald, Tanque Maribel, Tirador Louie, Villa Michael, Bautista Albert, Catindig Elizabeth, Manalo Carlo, Mirasol Roberto, Butrymowicz Patrycja, Ciechanowski Kazimierz, Cieslik Grazyna, Franek Edward, Gumprecht Janusz, Hoffmann Michal, Krzykowska Jolanta, Kurnatowska Ilona, Landa Katarzyna, Madrzejewski Adam, Madziarska Katarzyna, Mazur Stanislaw, Napora Piotr, Nowicki Michal, Ocicka-Kozakiewicz Anna, Rewerska Barbara, Rusicka Teresa, Ruxer Jan, Skokowska Ewa, Stankiewicz Andrzej, Stompor Tomasz, Tiuryn-Petrulewicz Agnieszka, Wasilewska Katarzyna, Wierusz-Wysocka Bogna, Wnetrzak-Michalska Renata, Jedynasty Krystyna, Sein Anand Izabela, Almeida Edgar, Ballesteros Rosa, Barreto Carlos, Beirao Idalina, Birne Rita, Esteves Cesar, Guia Jose, Heitor Susana, Marques Olinda, Melo Pedro, Nolasco Fernando, Pereira Amalia, Roque Cristina, Rosario Francisco, Silva Gil, Silva Ana, Teixeira e Costa Fernando, Vila Lobos Ana, Alves Ana Rita, Brandao Ilidio, Carvalho Rui, Coelho Joao, Lourenco Ana, Matos Pedro, Rosario Vanisa, Neves Joao Sergio, Cortes-Maisonet Gregorio, Roman-Miranda Amaury, Brito-Peguero Yudit, Colon-Vega Gildred, Albota Adrian, Bala Cornelia, Barbonta Hortensia, Caceaune Elena, Catrinoui Doina, Constantin Ciprian, Dumitrescu Adriana, Mindrescu Nicoleta, Mistode Cristina, Negrisanu Gabriela, Onaca Adriana, Paveliu Silvia, Pintilei Ella, Pop Lavinia, Popa Amorin, Popescu Alexandrina, Radulian Gabriela, Szilagyi Iosif, Turcu Liana, Vacaru Georgeta, Vlad Adrian, Filimon Adriana, Veresiu Ioan, Antsiferov Mikhail, Arkhipov Mikhail, Babkin Andrey, Barbarash Olga, Baranov Vitaliy, Chernyavskaya Elena, Demko Arkadiy, Dreval Alexander, Edin Anton, Ermakova Polina, Fadeev Valentin, Galyavich Albert, Gaysina Leyla, Gordeev Ivan, Ipatko Irina, Kalashnikova Marina, Khalimov Yuriy, Klimontov Vadim, Kobalava Zhanna, Kosmacheva Elena, Koziolova Natalya, Kvitkova Lyudmila, Levashov Sergey, Libis Roman, Marasaev Vyacheslav, Malykh Natalia, Martynenko Vladimir, Malyutina Sofya, Merai Imad, Mkrtumyan Ashot, Nechaeva Galina, Petunina Nina, Palyutin Shamil, Pimenov Leonid, Rechkova Elena, Rodionova Tatyana, Rymar Oksana, Sardinov Ruslan, Semenova Olga, Sherenkov Alexander, Solovev Oleg, Smolyarchuk Elena, Strongin Leonid, Ukhanova Olga, Verlan Nadezhda, Vorokhobina Natalya, Yakhontov Davyd, Yakushin Sergey, Zakharova Elena, Zalevskaya Alsu, Zanozina Olga, Zhdanova Elena, Zhukova Larisa, Zykova Tatyana, Argunova Yulia, Nikolaev Konstantin, Villevalde Svetlana, Sum Chee Fang, Suhail Sufi Muhummad, Tan Ru San, Vathsala Anantharaman, Wong Edmund, Bee Yong Mong, Babikova Jana, Buganova Ingrid, Dzupina Andrej, Ochodnicka Zuzana, Sosovec Dalibor, Spodniakova Denisa, Minarik Peter, Ahmed Fayzal, Amod Aslam, Bhana Sindeep, Distiller Larry, Jansen van Rensburg Dirkie, Joshi Mukesh, Joshi Shaifali, Lakha Deepak, Mitha Essack, Podgorski Gracjan, Ranjith Naresh, Rayner Brian, Rheeder Paul, Sarvan Mohamed, Seeber Mary, Siebert Heidi, Tayob Mohammed, Trokis Julien, Urbach Dorothea, van Zyl Louis, Jansen van Rensburg Dirkie, Choi Bum-Soon, Choi Moon Gi, Chung ChoonHee, Hwang YouCheol, Kim ChongHwa, Kim InJoo, Kim JaeHyeon, Kim SinGon, Kim SungGyun, Kim Tae Hee, Lee WooJe, Lee ByungWan, Lee Kang Wook, Oh Kook-Hwan, Oh Ji Eun, Oh Yun Kyu, Oh Dong-Jin, Park Junbeom, Shin Seok Joon, Sung Su-Ah, Yu Jae Myung, Chung HyeSoo, Huh Ji Hye, Kang JunGoo, Kim ChulSik, Kim HyeSoon, Kim NamHoon, Lim Soo, Cho Young Min, Young Park Cheol, Agraz Irene, Ampudia Francisco Javier, Bouarich Hanane, Calero Francesca, Castro Cristina, Cigarrán Guldris Secundino, Cruzado Garrit Josep, de Álvaro Fernando, Galcerán Josep, González Albarrán Olga, Hernández Jaras Julio, Ibernón Meritxell, Martínez Deben Francisco, Martínez Esteban Mª Dolores, Pascual Izuel José María, Martins Judith, Mediavilla Juan, Michán Alfredo, Santos Julio Pascual, Poch Esteban, Polaina Rusillo Manuel, Sánchez Juan Carlos, Santamaría Olmo Rafael, Segura de la Morena José Julián, Soto Alfonso, Troya Maribel, Cereto Castro Fernando, Gómez Fernández Pablo, Fuentes Sánchez Laura, González Moya Mercedes, Hernández Marrero Domingo, Piedrola Maroto Gonzalo, Redón Josep, Seron Daniel, Bruchfeld Annette, Curiac Dan, Eliasson Ken, Frank Malin, Guron Gregor, Hellberg Olof, Hellgren Margareta, Larnefeldt Hans, Lindholm Carl-Johan, Löndahl Magnus, Rein-Hedin Erik, Soveri Inga, Spaak Jonas, Tengmark Bengt-Olov, Lif-Tiberg Cornelia, Månflod Johan, Nguyen Han, Ackermann Daniel, Bilz Stefan, Burnier Michel, Forster Christian, Kalbermatter Stefan, Kistler Andreas, Pechère-Bertschi Antoinette, Schultes Bernd, Laimer Markus, Rudofsky Gottfried, Strey Christopher, Wuerzner Gregoire, Chang Chiz-Tzung, Hung Cheng-Chieh, Jiang Ju-Ying, Lee Chien-Te, Lin Shuei-Liong, Tarng Der-Cherng, Tu Shih-Te, Wu Mai-Szu, Wu Ming-Ju, Chuang Lee-Ming, Deerochanawong Chaicharn, Kitiyakara Chagriya, Ophascharoensuk Vuddhidej, Pongchaiyakul Chatlert, Satirapoj Bancha, Kosachunhanan Natapong, Sritara Piyamitr, Eren Necmi, Gul Ibrahim, Gulel Okan, Kocyigit Ismail, Kumbasar Abdulbaki, Sahin Idris, Sari Ramazan, Sayin Burak, Tavli Talat, Ustundag Sedat, Yenicerioglu Yavuz, Badak Ozer, Cayli Murat, Oguz Aytekin, Ozdogan Oner, Sari Ibrahim, Temizhan Ahmet, Tigen Mustafa, Turk Ugur, Yilmaz Huseyin, Yilmaz Mehmet, Bondarets Iryna, Botsyurko Volodymyr, Chernikova Viktoriia, Donets Oleksandra, Fushtey Ivan, Grachova Mariia, Isayeva Anna, Kogut Dmytro, Komisarenko Julia, Kravchun Nonna, Malyar Kateryna, Mankovsky Borys, Martynyuk Liliya, Maslyanko Vitaliy, Myshanych Halyna, Pererva Larysa, Pertseva Nataliia, Serhiyenko Oleksandr, Smirnov Ivan, Sokolova Liubov, Stryzhak Vasyl, Vlasenko Maryna, Isayeva Ganna, Larin Oleksandr, AbouSaleh Ahmad, Barratt Jonathan, Dang Cuong, Kahal Hassan, Kirk Adam, Kilvert Anne, Kon Sui Phi, McCafferty Kieran, Patel Dipesh, Rice Sam, Vijayaraman Arutchelvam, Wong Yuk-ki, Gibson Martin, Wahba Mona, Zaidi Reza, Bilous Rudy, Johnson Andrew, Kalathil Dhanya, Kilvert Anne, Kyriakidou Christina, Mathew Amit, Mukhtar Rasha, Munsoor Imrozia, Poterajlo Anton, Swift Pauline, Acosta Idalia, Adams Atoya, Adler Sharon, Ajani Dilawar, Ali Slamat, Alicic Radica, Al-Karadsheh Amer, Alla Sreedhara, Andrawis D. Allison Nabil, Arif Ahmed, Awad Ahmed, Azizad Masoud, Bahrami Michael, Bansal Shweta, Barag Steven, Barakzoy Ahmad, Barney Mark, Barzilay Joshua, Bashir Khalid, Bautista Jose, Beddhu Srinivasan, Belo Diogo, Benjamin Sabrina, Berenji Ramin, Bhargava Anuj, Birriel Jose, Brietzke Stephen, Brosius Frank, Brusco Osvaldo, Burgner Anna, Busch Robert, Canadas Rafael, Caramori Maria, Cardona Jose, Case Christopher, Cruz Humberto, Dandillaya Ramprasad, Dawoud Dalia, Din Zia, Dixon Bradley, Doshi Ankur, Drakakis James, El Shahawy Mahfouz, El-Meanawy Ashraf, El-Shahawy Mohammed, Evans John, Fadda George, Farooq Umar, Fernando Roland, Fink Raymond, First Brian, Fitz-Patrick David, Flack John, Fluck Patrick, Fogelfeld Leon, Fonseca Vivian, Frias Juan, Galphin Claude, Garcia-Mayol Luis, Goldstein Gary, Gonzalez Edgar, Gonzalez-Abreu Francisco, Gore Ashwini, Grant David, Habwe Violet, Hamilton Maxine, Hammoud Jamal, Handelsman Stuart, Hartman Israel, Heigerick Glenn, Henry Andrew, Hernandez German, Hernandez-Cassis Carlos, Herrera Carlos, Hertel Joachim, Huang Wenyu, Iglesias Rogelio, Iranmanesh Ali, Jackson Timothy, Jain Mahendra, Jamerson Kenneth, Johnson Karen, Judd Eric, Kaplan Joshua, Kayali Zeid, Khan Bobby, Khan Muhammad, Kharait Sourabh, Kirkman M. Sue, Kopyt Nelson, Kotzker Wayne, Kovesdy Csaba, Kreit Camil, Krishna Arvind, Kronfli Saeed, Lee Keung, LeJeune Derek, Lemus Brenda, Leon-Forero Carlos, Linfert Douglas, Lora Henry, Lurie Alexander, Maddukuri Geetha, Magno Alexander, Maletz Louis, Mandayam Sreedhar, Markell Mariana, Mayfield Ronald, Mbogua Caroline, McMullen Dierdre, Meisner Carl, Minton Stephen, Mocherla Bharat, Mohandas Rajesh, Montero Manuel, Moustafa Moustafa, Nadkarni Salil, Nakhle Samer, Navarro Jesus, Neyra Nilda, Nica Romanita, Nicol Philip, Norwood Paul, Numrungroad Visal, O’Donovan Richard, Odugbesan A., Paoli-Bruno Jorge, Parikh Samir, Patel Rakesh, Peixoto Aldo, Pergola Pablo, Perlman Alan, Pettis Karlton, Pisoni Roberto, Ponduchi Mirela, Posada Jorge, Prabhakar Sharma, Radhakrishnan Jai, Rahman Mahboob, Raina Rupesh, Rastogi Anjay, Reisin Efrain, Rendell Marc, Robertson David, Rocco Michael, Romeu Hugo, Rosas Sylvia, Rosenfeld Jack, Ross Dennis, Rothman Jeffrey, Rudolph Lance, Ruhullah Yusuf, Ruoff Gary, Ryu Jeffrey, Sahani Mandeep, Sam Ramin, Samuels Garfield, Sanchez William, Santos Vladimir, Satko Scott, Saxena Sanjeev, Scott David, Seco Gilberto, Seek Melvin, Serota Harvey, Shafi Tariq, Shahid Nauman, Shanik Michael, Sharma Santosh, Sinha Arjun, Smelser James, Smith Mark, Soe Kyaw, Solomon Richard, Soroka Eugene, Soufer Joseph, Spinowitz Bruce, Spry Leslie, Suarez Rosa, Subramanian Bala, Szerlip Harold, Tamirisa Aparna, Thomson Stephen, Tran Tuan-Huy, Treger Richard, Trullenque Gretel, Turk Thomas, Umpierrez Guillermo, Urbach Daniel, Valdes Martin, Valika Shujauddin, Vega Damaris, Weissman Peter, Whaley-Connell Adam, Winston Jonathan, Wise Jonathan, Wynne Alan, Zeig Steven, Abdel-Rahman Emaad, Abreu Edel, Awad Alaa, Bahri Nader, Bertsch John, Bleich David, Bornfreund Jonathan, Brar Harjeet, Brian Susan, Brinson Cynthia, Bruschetta Humberto, Carpio Jose, Cohen Steven, Cosby John, Dhanireddy Soni, Diaz Jorge, Dunn Fredrick, Eppanapally Sabitha, Fayad Joseph, Goel Archana, Govindaraju Kanakadurga, Halpern Stephen, Jones Audrey, Kaye William, Knight Herbert, Koch Stanley, Kohli Nandini, Lastra Guido, Lerman Sam, Loredo Jorge, Lovre Dragana, Mandviwala Mustafa, Martin Earl, Meyer Jill, Murray John, Oliver David, Oparil Suzanne, Penabad Jesus, Pereira Isabel, Popeil Larry, Quesada Gonzalo, Ramanathan Kodangudi, Ramos-Gonez Luis, Rastegar Mandana, Rastogi Padmashri, Rondon Juan, Roy-Chaudhury Prabir, Smith David, Williamson Don, Womack Catherine, Yamout Hala, Yuryev Michael, Chu Phuong, Hoang Lam Van, Khanh Tran, Nga Nguyen Thi Phi, Son Pham Nguyen, Tran Lan Phuong, Le Thuy Khuong, Nguyen Boi Ngoc, Nguyen Thao, Nui Nguyen Minh, Nam Tran Quang, Tran Kim Chi,
Affiliation:
1. 1Steno Diabetes Center Copenhagen, Herlev, Denmark 2. 2Department of Clinical Medicine, University of Copenhagen, Copenhagen, Denmark 3. 3Department of Cardiology (CVK) and Berlin Institute of Health Center for Regenerative Therapies, German Centre for Cardiovascular Research Partner Site Berlin, Charité–Universitätsmedizin, Berlin, Germany 4. 4School of Medicine, National and Kapodistrian University of Athens, Department of Cardiology, Attikon University Hospital, Athens, Greece 5. 5Department of Medicine, University of Michigan School of Medicine, Ann Arbor, MI 6. 6Cardiorenal Translational Laboratory and Hypertension Unit, Institute of Research Imas12, Madrid, Spain 7. 7CIBER-CV, Hospital Universitario 12 de Octubre, Madrid, Spain 8. 8Faculty of Sport Sciences, European University of Madrid, Madrid, Spain 9. 9German Center for Diabetes Research (DZD), München-Neuherberg, Germany 10. 10Department of Internal Medicine, Division of Diabetology, Endocrinology, and Nephrology, and Institute of Diabetes Research and Metabolic Diseases (IDM), Helmholtz Center Munich and University Hospital Tübingen, Tübingen, Germany 11. 11Division of Endocrinology, Metabolism and Lipid Research, Washington University in St. Louis, St. Louis, MO 12. 12Kidney and Hypertension Unit, Joslin Diabetes Center and Harvard Medical School, Boston, MA 13. 13Division of Nephrology, Department of Medicine, Beth Israel Deaconess Medical Center, Boston, MA 14. 14Cardiology and Nephrology Clinical Development, Bayer AG, Berlin, Germany 15. 15Statistics and Data Insights, Bayer AG, Wuppertal, Germany 16. 16Clinical Development, Bayer PLC, Reading, U.K 17. 17Medical Affairs and Pharmacovigilance, Pharmaceuticals, Bayer AG, Berlin, Germany 18. 18Department of Medicine, University of Chicago Medicine, Chicago, IL 19. 19Richard L. Roudebush VA Medical Center and Indiana University, Indianapolis, IN
Abstract
OBJECTIVE
Finerenone reduced the risk of kidney and cardiovascular events in people with chronic kidney disease (CKD) and type 2 diabetes in the FIDELIO-DKD and FIGARO-DKD phase 3 studies. Effects of finerenone on outcomes in patients taking sodium–glucose cotransporter 2 inhibitors (SGLT2is) were evaluated in a prespecified pooled analysis of these studies.
RESEARCH DESIGN AND METHODS
Patients with type 2 diabetes and urine albumin-to-creatinine ratio (UACR) ≥30 to ≤5,000 mg/g and estimated glomerular filtration rate (eGFR) ≥25 mL/min/1.73 m2 were randomly assigned to finerenone or placebo; SGLT2is were permitted at any time. Outcomes included cardiovascular composite (cardiovascular death, nonfatal myocardial infarction, nonfatal stroke, or hospitalization for heart failure) and kidney composite (kidney failure, sustained ≥57% eGFR decline, or renal death) end points, changes in UACR and eGFR, and safety outcomes.
RESULTS
Among 13,026 patients, 877 (6.7%) received an SGLT2i at baseline and 1,113 (8.5%) initiated one during the trial. For the cardiovascular composite, the hazard ratios (HRs) were 0.87 (95% CI 0.79–0.96) without SGLT2i and 0.67 (95% CI 0.42–1.07) with SGLT2i. For the kidney composite, the HRs were 0.80 (95% CI 0.69–0.92) without SGLT2i and 0.42 (95% CI 0.16–1.08) with SGLT2i. Baseline SGLT2i use did not affect risk reduction for the cardiovascular or kidney composites with finerenone (Pinteraction = 0.46 and 0.29, respectively); neither did SGLT2i use concomitant with study treatment.
CONCLUSIONS
Benefits of finerenone compared with placebo on cardiorenal outcomes in patients with CKD and type 2 diabetes were observed irrespective of SGLT2i use.
Publisher
American Diabetes Association
Subject
Advanced and Specialized Nursing,Endocrinology, Diabetes and Metabolism,Internal Medicine
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