1. 1Department of Internal Medicine, Joint Municipal Authority for North Karelia Social and Health Services (Siun Sote), Joensuu, Finland
2. 2Institute of Public Health and Clinical Nutrition, University of Eastern Finland, Kuopio, Finland
3. 3School of Pharmacy, University of Eastern Finland, Kuopio, Finland
4. 4Department of Public Health and Welfare, National Institute for Health and Welfare, Helsinki, Finland