Affiliation:
1. Elliott P. Joslin Research Laboratory, the Departments of Surgery and Medicine of the Peter Bent Brigham Hospital and Harvard Medical School Boston, Massachusetts
Abstract
Intravenous arginine infusions were performed in two totally pancreatectomized patients and two age/sex-matched normal subjects. Plasma glucagon concentrations did not increase in the pancreatectomized patients, whereas a four- to sixfold rise of the glucagon levels following arginine administration was seen in the control subjects. Measurements of plasma glucagon-like im-munoreactivity revealed no difference between normal and pancreatectomized subjects. The data suggest the absence of a significant number of normally functioning alpha cells in extrapancreatic sites.
Publisher
American Diabetes Association
Subject
Endocrinology, Diabetes and Metabolism,Internal Medicine
Cited by
71 articles.
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