Insulin Potentiating Action of a Peptide Fraction from Human Urine-Reference-Cited by-同舟云学术

Insulin Potentiating Action of a Peptide Fraction from Human Urine

Published:1974-12-01 Issue:12 Volume:23 Page:950-956
ISSN:0012-1797
Container-title:Diabetes
language:en
Short-container-title:

Author:

Ng Frank M¹,Zimmet Paul Z¹,Seiler Gwen¹,Taft Pincus¹,Bornstein Joseph¹

Affiliation:

1. Department of Biochemistry, Monash University, and The Ewen Downie Metabolic Unit, Alfred Hospital Melbourne, Australia

Abstract

An impure peptide preparation from human urine has been shown to have similar biological effects in vitro and in vivo to synthetic peptides containing the human growth hormone sequence Leu-Ser-Arg- Leu-Phe-Asp- Asn-Ala (residues 6–13). The urinary preparation potentiates the action of insulin in the isolated rat diaphragm and in rabbits and rats, but the latter animals are far more sensitive to its action. Species specificity is possibly a significant factor in determining dosage in future studies.

Publisher

American Diabetes Association

Subject

Endocrinology, Diabetes and Metabolism,Internal Medicine

Link

https://journals.org/diabetes/diabetes/article-pdf/23/12/950/347538/23-12-950.pdf

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