Common Polymorphisms in the Promoter of the Visfatin Gene (PBEF1) Influence Plasma Insulin Levels in a French-Canadian Population-Reference-Cited by-同舟云学术

Common Polymorphisms in the Promoter of the Visfatin Gene (PBEF1) Influence Plasma Insulin Levels in a French-Canadian Population

Published:2006-10-01 Issue:10 Volume:55 Page:2896-2902
ISSN:0012-1797
Container-title:Diabetes
language:en
Short-container-title:

Author:

Bailey Swneke D.¹,Loredo-Osti J C.²,Lepage Pierre³,Faith Janet³,Fontaine Joelle³,Desbiens Katia M.⁴,Hudson Thomas J.¹³⁴⁵,Bouchard Claude⁶,Gaudet Daniel⁷,Pérusse Louis⁸⁹,Vohl Marie-Claude⁹¹⁰,Engert James C.¹⁴⁵

Affiliation:

1. Department of Human Genetics, McGill University, Montréal, Québec, Canada

2. Department of Mathematic and Statistics, Memorial University of Newfoundland, St. John’s, Newfoundland, Canada

3. McGill University and Genome Québec Innovation Centre, Montréal, Québec, Canada

4. Research Institute of the McGill University Health Centre, Montréal, Québec, Canada

5. Department of Medicine, McGill University, Montréal, Québec, Canada

6. Pennington Biomedical Research Centre, Baton Rouge, Louisiana

7. Dyslipidemia, Diabetes and Atherosclerosis Group and Community Genomics Research Center, Université de Montréal and Chicoutimi Hospital, Québec, Canada

8. Department of Social and Preventive Medicine, Division of Kinesiology, Laval University, Québec, Canada

9. Lipid Research Center, Laval University Hospital Research Center, Québec, Canada

10. Department of Food Science and Nutrition, Laval University, Québec, Canada

Abstract

The adipokine visfatin (PBEF1) exhibits insulin-mimetic effects and correlates strongly with visceral adiposity. We sequenced visfatin gene exons and 1,480 bp of the promoter in 23 individuals, including 18 individuals from the Quebec Family Study (QFS) with varying degrees of abdominal visceral fat, assessed by computed tomography, and 5 individuals from the Saguenay-Lac-Saint-Jean region of Québec. We identified a synonymous polymorphism in exon 7 (SER301SER) but no nonsynonymous mutations. We observed an additional 10 polymorphisms, including 5 intronic, 4 within the promoter, and 1 within the 3′ untranslated region. Further promoter sequencing (816 bp) identified five additional single nucleotide polymorphisms (SNPs) in the QFS population. To investigate the role of visfatin gene variants in obesity-related phenotypes, we genotyped a total of 13 SNPs in the promoter region of the gene. From these, we analyzed the seven common SNPs in the QFS sample (918 participants from 208 families). A significant association was found between two SNPs (rs9770242 and rs1319501), in perfect linkage disequilibrium, and fasting insulin levels (P = 0.002). These SNPs were also associated with fasting glucose (P ≤ 0.02). In addition, a more distal SNP (rs7789066) was significantly associated with the apolipoprotein B component of VLDL (P = 0.012).

Publisher

American Diabetes Association

Subject

Endocrinology, Diabetes and Metabolism,Internal Medicine

Link

https://journals.org/diabetes/diabetes/article-pdf/55/10/2896/339910/zdb01006002896.pdf

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