Nontraditional Markers of Glycemia

Author:

Selvin Elizabeth123,Francis Lesley M.A.1,Ballantyne Christie M.4,Hoogeveen Ron C.4,Coresh Josef123,Brancati Frederick L.123,Steffes Michael W.5

Affiliation:

1. Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland

2. Welch Center for Prevention, Epidemiology and Clinical Research, Johns Hopkins University, Baltimore, Maryland

3. Division of General Internal Medicine, Department of Medicine, Johns Hopkins University, Baltimore, Maryland

4. Department of Medicine, Baylor College of Medicine and Methodist DeBakey Heart and Vascular Center, Houston, Texas

5. Department of Laboratory Medicine and Pathology, Medical School, University of Minnesota, Minneapolis, Minneapolis

Abstract

OBJECTIVE To compare the associations of nontraditional (fructosamine, glycated albumin, 1,5-anhydroglucitol [1,5-AG]) and standard (fasting glucose, HbA1c) glycemic markers with common microvascular conditions associated with diabetes mellitus. RESEARCH DESIGN AND METHODS We conducted a cross-sectional study of 1,600 participants (227 with a history of diabetes and 1,323 without) from the Atherosclerosis Risk in Communities (ARIC) Study, a community-based population. We conducted logistic regression analyses of the associations of diabetes-specific tertiles of fructosamine, glycated albumin, 1/(1,5-AG), fasting glucose, and HbA1c with prevalence of chronic kidney disease, albuminuria, and retinopathy after adjustment for demographic, clinical, and lifestyle variables. RESULTS We observed significant positive trends in the associations of each marker with albuminuria and retinopathy, even after accounting for demographic, clinical, and lifestyle factors (all P trends <0.05). The associations with chronic kidney disease were similar in direction but were only significant for higher glycated albumin (P trend = 0.005), fructosamine (P trend = 0.003), and HbA1c (P trend = 0.005) values. After further adjustment for HbA1c, glycated albumin and fructosamine remained significantly or borderline significantly associated with the microvascular outcomes. CONCLUSIONS In cross-sectional analyses, two serum markers of glycemia—glycated albumin and fructosamine—are as, or more strongly, associated with microvascular conditions as HbA1c. These markers may be useful in settings where whole blood is not available. Whether they might complement or outperform HbA1c in terms of long-term predictive value requires further investigation.

Publisher

American Diabetes Association

Subject

Advanced and Specialized Nursing,Endocrinology, Diabetes and Metabolism,Internal Medicine

Cited by 109 articles. 订阅此论文施引文献 订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献

同舟云学术

1.学者识别学者识别

2.学术分析学术分析

3.人才评估人才评估

"同舟云学术"是以全球学者为主线,采集、加工和组织学术论文而形成的新型学术文献查询和分析系统,可以对全球学者进行文献检索和人才价值评估。用户可以通过关注某些学科领域的顶尖人物而持续追踪该领域的学科进展和研究前沿。经过近期的数据扩容,当前同舟云学术共收录了国内外主流学术期刊6万余种,收集的期刊论文及会议论文总量共计约1.5亿篇,并以每天添加12000余篇中外论文的速度递增。我们也可以为用户提供个性化、定制化的学者数据。欢迎来电咨询!咨询电话:010-8811{复制后删除}0370

www.globalauthorid.com

TOP

Copyright © 2019-2024 北京同舟云网络信息技术有限公司
京公网安备11010802033243号  京ICP备18003416号-3