Virus Antibody Survey in Different European Populations Indicates Risk Association Between Coxsackievirus B1 and Type 1 Diabetes

Author:

Oikarinen Sami1,Tauriainen Sisko12,Hober Didier3,Lucas Bernadette3,Vazeou Andriani4,Sioofy-Khojine Amirbabak1,Bozas Evangelos4,Muir Peter5,Honkanen Hanna1,Ilonen Jorma67,Knip Mikael891011,Keskinen Päivi10,Saha Marja-Terttu10,Huhtala Heini12,Stanway Glyn13,Bartsocas Christos4,Ludvigsson Johnny14,Taylor Keith15,Hyöty Heikki116,

Affiliation:

1. Department of Virology, University of Tampere, Tampere, Finland

2. Department of Virology, University of Turku, Turku, Finland

3. Laboratory of Virology EA3610, University Lille 2 and CHR, Lille, France

4. Department of Pediatrics, Faculty of Nursing, National University of Athens, Athens, Greece

5. King's College London, London, U.K.

6. Immunogenetics Laboratory, University of Turku, Turku, Finland

7. Department of Clinical Microbiology, University of Eastern Finland, Kuopio, Finland

8. Folkhälsan Research Center, Helsinki, Finland

9. Children’s Hospital, University of Helsinki and Helsinki University Central Hospital, Helsinki, Finland

10. Department of Pediatrics, Tampere University Hospital and University of Tampere, Tampere, Finland

11. Diabetes and Obesity Research Program, University of Helsinki, Helsinki, Finland

12. School of Health Sciences, University of Tampere, Tampere, Finland

13. Department of Biological Sciences, University of Essex, Colchester, U.K.

14. Division of Pediatrics, Department of Clinical and Experimental Medicine, Linköping University, Linköping, Sweden

15. Queen Mary and Westfield College, London, U.K.

16. Fimlab Laboratories, Pirkanmaa Hospital District, Tampere, Finland

Abstract

Enteroviruses (EVs) have been connected to type 1 diabetes in various studies. The current study evaluates the association between specific EV subtypes and type 1 diabetes by measuring type-specific antibodies against the group B coxsackieviruses (CVBs), which have been linked to diabetes in previous surveys. Altogether, 249 children with newly diagnosed type 1 diabetes and 249 control children matched according to sampling time, sex, age, and country were recruited in Finland, Sweden, England, France, and Greece between 2001 and 2005 (mean age 9 years; 55% male). Antibodies against CVB1 were more frequent among diabetic children than among control children (odds ratio 1.7 [95% CI 1.0–2.9]), whereas other CVB types did not differ between the groups. CVB1-associated risk was not related to HLA genotype, age, or sex. Finnish children had a lower frequency of CVB antibodies than children in other countries. The results support previous studies that suggested an association between CVBs and type 1 diabetes, highlighting the possible role of CVB1 as a diabetogenic virus type.

Publisher

American Diabetes Association

Subject

Endocrinology, Diabetes and Metabolism,Internal Medicine

Reference34 articles.

1. Virus infections in type 1 diabetes;Coppieters;Cold Spring Harb Perspect Med,2012

2. Duration of virus persistence and its relationship to inflammation in the chronic phase of coxsackievirus B1-induced murine polymyositis;Tam;J Lab Clin Med,1994

3. Hepatitis delta virus proteins repress hepatitis B virus enhancers and activate the alpha/beta interferon-inducible MxA gene;Williams;J Gen Virol,2009

4. Enterovirus infection and type 1 diabetes mellitus: systematic review and meta-analysis of observational molecular studies;Yeung;BMJ,2011

5. Coxsackie B virus serology and type 1 diabetes mellitus: a systematic review of published case-control studies;Green;Diabet Med,2004

同舟云学术

1.学者识别学者识别

2.学术分析学术分析

3.人才评估人才评估

"同舟云学术"是以全球学者为主线,采集、加工和组织学术论文而形成的新型学术文献查询和分析系统,可以对全球学者进行文献检索和人才价值评估。用户可以通过关注某些学科领域的顶尖人物而持续追踪该领域的学科进展和研究前沿。经过近期的数据扩容,当前同舟云学术共收录了国内外主流学术期刊6万余种,收集的期刊论文及会议论文总量共计约1.5亿篇,并以每天添加12000余篇中外论文的速度递增。我们也可以为用户提供个性化、定制化的学者数据。欢迎来电咨询!咨询电话:010-8811{复制后删除}0370

www.globalauthorid.com

TOP

Copyright © 2019-2024 北京同舟云网络信息技术有限公司
京公网安备11010802033243号  京ICP备18003416号-3