Affiliation:
1. Veterans Administration Hospital and Georgetown, University School of Medicine Washington, D.C. Washington University School of Medicine St. Louis, Missouri
Abstract
A reproducible pattern of change in insulin inhibitory activity associated with plasma albumin has been demonstrated. In six normal subjects, intravenous Na tolbutamide increased inhibitor activity to levels seen in many diabetics. Similar increases were seen in certain diabetic patients but not in all. Intravenous exogenous insulin also increased inhibitory activity. Since the latter could be demonstrated in the absence of hypoglycemia, the increase in inhibitor was probably related to the increase in insulin molecules. The time of inhibitor appearance suggests that it may be a product of insulin metabolism but other possibilities exist.
Publisher
American Diabetes Association
Subject
Endocrinology, Diabetes and Metabolism,Internal Medicine
Cited by
5 articles.
订阅此论文施引文献
订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献