Youth-Onset Type 2 Diabetes Consensus Report: Current Status, Challenges, and Priorities

Author:

Nadeau Kristen J.1,Anderson Barbara J.2,Berg Erika G.3,Chiang Jane L.3,Chou Hubert4,Copeland Kenneth C.5,Hannon Tamara S.6,Huang Terry T.-K.7,Lynch Jane L.8,Powell Jeff9,Sellers Elizabeth10,Tamborlane William V.11,Zeitler Philip1

Affiliation:

1. Department of Pediatrics, University of Colorado School of Medicine, and Department of Endocrinology, Children's Hospital Colorado, Aurora, CO

2. Section of Psychology, Department of Pediatrics, Baylor College of Medicine Education at Texas Children’s Hospital, Houston, TX

3. American Diabetes Association, Alexandria, VA

4. Clinical Development, Daiichi Sankyo, New York, NY

5. Department of Pediatrics and Harold Hamm Diabetes Center–Children’s, The University of Oklahoma College of Medicine, Oklahoma City, OK

6. Indiana University School of Medicine, Indianapolis, IN

7. School of Public Health, The City University of New York, New York, NY

8. The University of Texas Health Science Center at San Antonio, San Antonio, TX

9. Pediatrics and Community Health, Northern Navajo Medical Center, Navajo Area Indian Health Service, Shiprock, NM

10. Department of Pediatrics, Health Sciences Centre Winnipeg, Winnipeg, Canada

11. Department of Pediatric Endocrinology and Yale Center for Clinical Investigation, Yale School of Medicine, New Haven, CT

Abstract

Type 2 diabetes is a significant and increasing burden in adolescents and young adults. Clear strategies for research, prevention, and treatment of the disease in these vulnerable patients are needed. Evidence suggests that type 2 diabetes in children is different not only from type 1 but also from type 2 diabetes in adults. Understanding the unique pathophysiology of type 2 diabetes in youth, as well as the risk of complications and the psychosocial impact, will enable industry, academia, funding agencies, advocacy groups, and regulators to collectively evaluate both current and future research, treatment, and prevention approaches. This Consensus Report characterizes type 2 diabetes in children, evaluates the fundamental differences between childhood and adult disease, describes the current therapeutic options, and discusses challenges to and approaches for developing new treatments.

Publisher

American Diabetes Association

Subject

Advanced and Specialized Nursing,Endocrinology, Diabetes and Metabolism,Internal Medicine

Reference69 articles.

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5. Global trends in the incidence and prevalence of type 2 diabetes in children and adolescents: a systematic review and evaluation of methodological approaches;Fazeli Farsani;Diabetologia,2013

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