Normal Glucose Values Are Associated With a Lower Risk of Mortality in Hospitalized Patients

Author:

Bruno Alberto1,Gregori Dario2,Caropreso Antonio3,Lazzarato Fulvio4,Petrinco Michele2,Pagano Eva4

Affiliation:

1. Diabetologia ASO San Giovanni Battista of Turin, Turin, Italy

2. Department of Public Health and Microbiology, University of Turin, Turin, Italy

3. Central Laboratory ASO San Giovanni Battista of Turin, Turin, Italy

4. Unit of Cancer Epidemiology, CPO Piemonte, University of Turin, Turin, Italy

Abstract

OBJECTIVE—Hyperglycemia is a common condition in hospitalized patients. The aim of this study was to investigate the relationships between glycemia upon admission and mortality in a heterogeneous group of adult patients. RESEARCH DESIGN AND METHODS—The 3-year records released from a general hospital were associated with a plasma glucose dataset of its general laboratory. A matched case-control study was implemented (3,338 case-control subject pairs). All-patient refined diagnosis–related groups and the relative risk of death were the matching criteria. A multivariate conditional logistic regression model was used to evaluate the associations between death and glycemia. RESULTS—Higher in-hospital mortality was associated with hyperglycemia or hypoglycemia, whereas lower risk was observed for values between 78 and 101 mg/dl. CONCLUSIONS—Our data confirm the relation between glycemia upon admission and mortality and suggest that slightly increased or decreased plasma glucose can be linked with increased mortality risk.

Publisher

American Diabetes Association

Subject

Advanced and Specialized Nursing,Endocrinology, Diabetes and Metabolism,Internal Medicine

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