Differential Patterns of Impaired Cardiorespiratory Fitness and Cardiac Autonomic Dysfunction in Recently Diagnosed Type 1 and Type 2 Diabetes

Author:

Röhling Martin12,Strom Alexander12,Bönhof Gidon1,Püttgen Sonja1,Bódis Kálmán12,Müssig Karsten123,Szendrödi Julia123,Markgraf Daniel12,Lehr Stefan24,Roden Michael123,Ziegler Dan123,

Affiliation:

1. Institute for Clinical Diabetology, German Diabetes Center, Leibniz Center for Diabetes Research at Heinrich Heine University Düsseldorf, Düsseldorf, Germany

2. German Center for Diabetes Research, München-Neuherberg, Germany

3. Department of Endocrinology and Diabetology, Medical Faculty, Heinrich Heine University, Düsseldorf, Germany

4. Institute of Clinical Biochemistry and Pathobiochemistry, German Diabetes Center, Heinrich Heine University Düsseldorf, Düsseldorf, Germany

Abstract

OBJECTIVE Both impaired cardiorespiratory fitness (CRF) and heart rate variability (HRV) are predictors of mortality, but their relative roles in recent-onset diabetes are unknown. We determined to which extent CRF and HRV are reduced and interrelated in recent-onset diabetes. RESEARCH DESIGN AND METHODS Participants from the German Diabetes Study with type 1 (n = 163) or type 2 (n = 188) diabetes with known diabetes duration <1 year and two age-matched glucose-tolerant control groups (n = 40 each) underwent spiroergometry and HRV assessment during a hyperinsulinemic-euglycemic clamp. RESULTS Compared with control subjects, patients with type 2 diabetes showed reduced VO2max (median [1st–3rd quartiles] 19.3 [16.5–22.9] vs. 25.6 [20.7–29.9] mL/kg body weight/min; P < 0.05), diminished VCO2max (23.0 [19.1–26.8] vs. 30.9 [24.5–34.4] mL/kg body weight/min; P < 0.05), blunted heart rate recovery after 2 min (−29.0 [−35.0 to −23.0] vs. −36.0 [−42.8 to −28.0] beats/min; P < 0.05), and reduced HRV in four of nine indices, whereas patients with type 1 diabetes had unaltered CRF but reduced HRV in three of nine indices (P < 0.05), indicating diminished vagal and sympathetic HRV modulation. HRV measures correlated with VO2max in patients with type 1 diabetes (r >0.34; P < 0.05) but not in those with type 2 diabetes. CONCLUSIONS CRF is reduced in recently diagnosed type 2 diabetes but preserved in type 1 diabetes, whereas cardiac autonomic function is reduced in both diabetes types but is strongly associated with CRF only in type 1 diabetes. These results support the therapeutic concept of promoting physical fitness in the early course of diabetes.

Funder

Ministry of Science and Research of the State of North Rhine-Westphalia

German Federal Ministry of Health

Federal Ministry for Research

Ministry of Science and Research of the State of North Rhine-Westphalia (MIWF NRW)

German Federal Ministry of Health (BMG)

Federal Ministry for Research (BMBF)

Publisher

American Diabetes Association

Subject

Advanced and Specialized Nursing,Endocrinology, Diabetes and Metabolism,Internal Medicine

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