Affiliation:
1. Department of Pathology, University of Massachusetts Medical School Worcester, Massachusetts
Abstract
Elimination of environmental viruses by cesarean derivation of the University of Massachusetts colony of BB/Wor rats increased the frequency and accelerated the tempo of spontaneous diabetes among diabetes-prone (DP) rats. In contrast, the viral-antibody–free (VAF) environment did not alter the resistance of pre-VAF diabetes-resistant (DR) rats to spontaneous and RT6+ T-lymphocyte–depletion–induced diabetes. Pre-VAF and VAF rats have essentially the same lymphocyte subsets, and VAF-DP rats are susceptible to the adoptive transfer of diabetes and to the diabetes-accelerating effects of polyinosinic-polycytidylic acid injections. These results suggest that the presence of environmental viral pathogens may act to inhibit effector cell function in lymphopenic DP rats while enhancing effector cell activity in nonlymphopenic DR rats.
Publisher
American Diabetes Association
Subject
Endocrinology, Diabetes and Metabolism,Internal Medicine
Cited by
49 articles.
订阅此论文施引文献
订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献
1. The Protective Discourse Between Infections and Autoimmunity;Role of Microorganisms in Pathogenesis and Management of Autoimmune Diseases;2022
2. Placental structure in gestational diabetes mellitus;Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease;2020-02
3. Childhood Obesity and Diabetes: Role of Probiotics and Prebiotics;Global Perspectives on Childhood Obesity;2019
4. Diabète et environnement;Diabétologie de L'enfant;2018
5. Animal Models of Type 1 and Type 2 Diabetes Mellitus;Animal Models for the Study of Human Disease;2017