Studies on the Site and Mechanism of Action of Phenformin: II. Phenformin Inhibition of Glucose Transport by Rat Intestine-Reference-Cited by-同舟云学术

Studies on the Site and Mechanism of Action of Phenformin: II. Phenformin Inhibition of Glucose Transport by Rat Intestine

Published:1970-01-01 Issue:1 Volume:19 Page:50-52
ISSN:0012-1797
Container-title:Diabetes
language:en
Short-container-title:

Author:

Kruger Fred A¹,Altschuld Ruth A¹,Hollobaugh Samuel L¹,Jewett Barbara¹

Affiliation:

1. Division of Endocrinology and Metabolism, Department of Medicine, Ohio State University Hospitals Columbus, Ohio

Abstract

The effect of oral phenformin on the active transport of glucose by everted sacs of rat intestine was investigated. Pretreatment of the animals with a single dose of the drug resulted in an inhibition of active transport. A log-dose relationship was found in the range studied (5 to 150 mg./kg.). These findings could explain the observation that phenformin increases the tolerance to orally administered glucose but has no effect on intravenous glucose tolerance in humans.

Publisher

American Diabetes Association

Subject

Endocrinology, Diabetes and Metabolism,Internal Medicine

Link

https://journals.org/diabetes/diabetes/article-pdf/19/1/50/345062/19-1-50.pdf

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