Diabetogenic Effects of Streptozotocin in Rhesus Monkeys

Author:

Pitkin Roy M1,Reynolds W Ann1

Affiliation:

1. Department of Obstetrics and Gynecology, University of Iowa Hospitals Iowa City, Iowa Department of Anatomy, University of Illinois at the Medical Center Chicago, Illinois

Abstract

Streptozotocin was administered to twelve rhesus monkeys in single intravenous doses of 30, 45, or 60 mg. per kg. Post-treatment study of plasma glucose and immunoreactive insulin levels and pancreatic histology confirmed previous observations in lower animals that streptozotocin produces a diabetic-like state due to its cytotoxic action on pancreatic beta cells. In contrast to its reported effect in rodents, however, streptozotocin in monkeys was somewhat more variable in its diabetogenic action and appeared to have a narrower margin of safety between diabeto genesis and toxicity. Of seven animals given 45 mg. per kg., five developed hyperglycemia and relative hypoinsulinemia and a sixth had impaired glucose tolerance. Two monkeys, both receiving 60 mg. per kg., became frankly diabetic while all three receiving 30 mg. per kg. showed no alteration in glucose tolerance.

Publisher

American Diabetes Association

Subject

Endocrinology, Diabetes and Metabolism,Internal Medicine

Cited by 106 articles. 订阅此论文施引文献 订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献

同舟云学术

1.学者识别学者识别

2.学术分析学术分析

3.人才评估人才评估

"同舟云学术"是以全球学者为主线,采集、加工和组织学术论文而形成的新型学术文献查询和分析系统,可以对全球学者进行文献检索和人才价值评估。用户可以通过关注某些学科领域的顶尖人物而持续追踪该领域的学科进展和研究前沿。经过近期的数据扩容,当前同舟云学术共收录了国内外主流学术期刊6万余种,收集的期刊论文及会议论文总量共计约1.5亿篇,并以每天添加12000余篇中外论文的速度递增。我们也可以为用户提供个性化、定制化的学者数据。欢迎来电咨询!咨询电话:010-8811{复制后删除}0370

www.globalauthorid.com

TOP

Copyright © 2019-2024 北京同舟云网络信息技术有限公司
京公网安备11010802033243号  京ICP备18003416号-3