Patients With Diabetes and Chronic Liver Disease Are at Increased Risk for Overall Mortality: A Population Study From the United States

Author:

Stepanova Maria12,Clement Stephen3,Wong Robert4,Saab Sammy5,Ahmed Aijaz67,Younossi Zobair M.128

Affiliation:

1. Center for Liver Diseases, Inova Fairfax Hospital, Falls Church, VA

2. Betty and Guy Beatty Center for Integrated Research, Inova Health System, Falls Church, VA

3. Section of Endocrinology, Department of Medicine, Inova Fairfax Hospital, Falls Church, VA

4. Division of Gastroenterology and Hepatology, Alameda Health System—Highland Hospital Campus, Oakland, CA

5. Departments of Medicine and Surgery, David Geffen School of Medicine, University of California at Los Angeles, Los Angeles, CA

6. Department of Surgery, Stanford University School of Medicine, Stanford, CA

7. Division of Gastroenterology and Hepatology, Department of Medicine, Stanford University School of Medicine, Stanford, CA

8. Department of Medicine, Inova Fairfax Hospital, Falls Church, VA

Abstract

IN BRIEF Chronic liver disease (CLD) and type 2 diabetes have both been linked to increased morbidity and mortality. In this study, the impact of CLD and diabetes on all-cause mortality was quantified at the population level using U.S. population data. Both type 2 diabetes and CLD were found to be independently associated with increased mortality (age-adjusted hazard ratio [aHR] 1.98 and 1.37 for diabetes and CLD, respectively), and having both diabetes and CLD substantially increased the risk of mortality (aHR 2.41).

Publisher

American Diabetes Association

Subject

Endocrinology, Diabetes and Metabolism,Internal Medicine

Reference20 articles.

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3. Centers for Disease Control and Prevention/National Center for Health Statistics . Health Interview Survey, 1997–2014: sample adult core component. Early release of selected estimates based on data from the National Health Interview Survey, 2014: diagnosed diabetes [Internet]. Available from http://www.cdc.gov/nchs/data/nhis/earlyrelease/earlyrelease201506_14.pdf. Accessed 20 June 2016

4. Centers for Disease Control and Prevention/National Center for Health Statistics . Health Interview Survey, 1997–2014: sample adult core component. Early release of selected estimates based on data from the National Health Interview Survey, 2014: diagnosed obesity [Internet]. Available from http://www.cdc.gov/nchs/data/nhis/earlyrelease/earlyrelease201506_06.pdf. Accessed 20 June 2016

5. Prevalence of obesity and trends in the distribution of body mass index among US adults, 1999–2010;Flegal;JAMA,2012

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